Results 31 to 40 of about 64,632 (290)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Bayesian estimation of one-parameter qubit gates

, 2008
We address estimation of one-parameter unitary gates for qubit systems and seek for optimal probes and measurements. Single- and two-qubit probes are analyzed in details focusing on precision and stability of the estimation procedure.
Barndorff-Nielsen O E, Berihu Teklu, Bernardo J M, Braunstein S L, Braunstein S L, Cam L Le, Chuang I L, Cover T M, Cramer H, D'Ariano G M, D'Ariano G M, Hayashi M, Helstrom C W, Holevo A S, Lehmann E L, Matteo G A Paris, Paris M G A, Poor H V, Schützenberger M P, Stefano Olivares, Trees H L van, Van Trees H L   +21 more
core   +1 more source

A simple minimax estimator for quantum states [PDF]

, 2012
Quantum tomography requires repeated measurements of many copies of the physical system, all prepared by a source in the unknown state. In the limit of very many copies measured, the often-used maximum-likelihood (ML) method for converting the gathered ...
BERTHOLD-GEORG ENGLERT, HUI KHOON NG, Lehmann E. L.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

PENERAPAN METODE SAE DENGAN PENDEKATAN EMPIRICAL BAYES BERBASIS MODEL BETA BINOMIAL PADA DATA BANGKITAN

Media Statistika, 2021
Small Area Estimation (SAE) is one of the statistical methods that used to estimate parameters of model from small subpopulations. Because of that, additional information is needed to predict these parameters that will result a more accurate predictive ...
Ferra Yanuar, Rahmatika Fajriyah, Dodi Devianto   +2 more
doaj   +1 more source

On Bayesian robust regression with diverging number of predictors

, 2016
This paper concerns the robust regression model when the number of predictors and the number of observations grow in a similar rate. Theory for M-estimators in this regime has been recently developed by several authors [El Karoui et al., 2013, Bean et al.
Nevo, Daniel, Ritov, Ya'acov
core   +1 more source

The Bayesian Analysis of Complex, High-Dimensional Models: Can It Be CODA? [PDF]

, 2014
We consider the Bayesian analysis of a few complex, high-dimensional models and show that intuitive priors, which are not tailored to the fine details of the model and the estimated parameters, produce estimators which perform poorly in situations in ...
Bickel, P. J., Gamst, A. C., Kleijn, B. J. K., Ritov, Y.   +3 more
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Bayesian Analysis for the Modified Frechet–Exponential Distribution with Covid-19 Application

Cumhuriyet Science Journal, 2023
In this manuscript, the maximum likelihood estimators and Bayes estimators for the parameters of the modified Frechet–exponential distribution. Because the Bayes estimators cannot be obtained in closed forms, the approximate Bayes estimators are computed
Neriman Akdam
doaj   +1 more source