Results 31 to 40 of about 9,519 (266)

BAYES RISKS OF ESTIMATORS OF ESTIMABLE PARAMETERS [PDF]

Bulletin of Mathematical Statistics, 1980
For the estimable parameter of degree 2, throughout this paper, we consider 02 with h2 such that h2(x, x) and h2(x, x)=0 for any x, yEX. As estimators of estimable parameters, U-statistics and differentiable statistical functions are well known. (See, for example, Hoeffding (1948) and von Mises (1947).) For an estimable parameter of degree 1, the U ...
openaire   +2 more sources

Stress-Strength Analysis of Inverse Weibull Model Using Type-II Progressive Hybrid Censoring and Its Application to Light-Emitting Diodes [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Tiǧāriyyaẗ
In this paper, we discuss the estimation of δ = P(Y < X) based on Type-II progressivehybrid censored samples when X and Y are two independent Inverse Weibull distributionswith different scale parameters, but having the same shape parameter.
سارة محمد عبدالعليم, محمد السيد ميعاد, ,وائل شحتة أبوالعزم   +2 more
doaj   +1 more source

Estimation of the Parameters of Burr Type III Distribution Based on Dual Generalized Order Statistics

The Scientific World Journal, 2014
The estimation of the parameters of Burr type III distribution based on dual generalized order statistics is considered by using the maximum likelihood (ML) approach as well as the Bayesian approach.
Chansoo Kim, Woosuk Kim
doaj   +1 more source

Statistical Inference for Lindley Model based on Type II Censored Data [PDF]

Journal of Statistical Theory and Applications (JSTA), 2017
In this paper, the moment-based, maximum likelihood and Bayes estimators for the unknown parameter of the Lindley model based on Type II censored data are discussed.
A. Asgharzadeh, H.K.T. Ng, R. Valiollahi, M. Azizpour   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bayesian Analysis of the Parameters of a Doubly Truncated Weibull Distribution [PDF]

The Egyptian Statistical Journal, 1992
In this paper, Bayes estimator of the scale and shape parameters of a doubly truncated Weibull distribution has been obtained. Also, credible and Shortest credible intervals have been obtained along write the Bayes estimates of the reliability function ...
O.A. Shalaby, M.H. Al Yousef
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source