Results 51 to 60 of about 832,071 (345)

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia   +6 more
wiley   +1 more source

On a design consistency property of hierarchical Bayes estimators in finite population samplings. [PDF]

open access: yes, 2007
We obtain a limit of a hierarchical Bayes estimator of a finite population mean when the sample size is large. The limit is in the sense of ordinary calculus, where the sample observations are treated as fixed quantities. Our result suggests a simple way
Lahiri, P, Mukherjee, Kanchan
core  

On the UMVUE and Closed-Form Bayes Estimator for $Pr(X [PDF]

open access: yes, 2023
This article considers the parametric estimation of $Pr ...
Rasethuntsa, Tau Raphael
core   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

Asymptotic Behavior of Bayes' Estimates

open access: yesThe Annals of Mathematical Statistics, 1964
This paper extends some of the results obtained by Freedman [2]. In Section 1 a class of prior distributions on the space of all substochastic distributions on the positive integers is given, such that along almost all sample sequences the corresponding posterior distributions of the expectations of all bounded functions on the positive integers are ...
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On Inconsistent Bayes Estimates of Location

open access: yesThe Annals of Statistics, 1986
This paper is related to the authors paper ibid. 14, 1-26 (1986; see the foregoing review, Zbl 0595.62022). In some relatively natural settings, Bayes estimates of location are shown to be inconsistent.
Diaconis, P., Freedman, D.
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Bayes linear covariance matrix adjustment [PDF]

open access: yes, 1995
In this thesis, a Bayes linear methodology for the adjustment of covariance matrices is presented and discussed. A geometric framework for quantifying uncertainties about covariance matrices is set up, and an inner-product for spaces of random matrices ...
Wilkinson, Darren James
core  

The Bayes estimator in a misspecified linear regression model [PDF]

open access: yes
Linear Regression Model, Misspecification, Optimal Bayes Estimator, Admissibility, Prediction,
L. Wei, G. Trenkler
core   +1 more source

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