Results 41 to 50 of about 64,632 (290)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Bayes Shrinkage Estimation of the Parameter of Rayleigh Distribution for Progressive Type-II Censored Data

Austrian Journal of Statistics, 2015
This paper derives Bayes shrinkage estimator of Rayleigh parameter and its associated risk based on conjugate prior under the assumption of general entropy loss function for progressive type-II censored data. Risk function of maximum likelihood estimate,
Sanku Dey, Tanujit Dey, Sudhansu S. Maiti   +2 more
doaj   +1 more source

Estimation of Pianka Overlapping Coefficient for Two Exponential Distributions

Mathematics, 2023
Overlapping coefficients (OVL) are commonly used to estimate the similarity between populations in terms of their density functions. In this paper, we consider Pianka’s overlap coefficient for two exponential populations.
Suad Alhihi, Maalee Almheidat
doaj   +1 more source

Empirical Bayes Derivative Estimates

Multivariate Behavioral Research, 2019
A dynamic system is a set of interacting elements characterized by changes occurring over time. The estimation of derivatives is a mainstay for exploring dynamics of constructs, particularly when the dynamics are complicated or unknown. The presence of measurement error in many social science constructs frequently results in poor estimates of ...
openaire   +2 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Odds Ratios Estimation of Rare Event in Binomial Distribution

Journal of Probability and Statistics, 2016
We introduce the new estimator of odds ratios in rare events using Empirical Bayes method in two independent binomial distributions. We compare the proposed estimates of odds ratios with two estimators, modified maximum likelihood estimator (MMLE) and ...
Kobkun Raweesawat, Yupaporn Areepong, Katechan Jampachaisri, Saowanit Sukparungsee   +3 more
doaj   +1 more source

IDENTIFICATION OF RAINFALL DISTRIBUTION IN WEST SUMATERA AND ASSESSMENT OF ITS PARAMETERS USING BAYES METHOD

Media Statistika, 2020
One distribution of rainfall data is a lognormal distribution with location parameters  and scale parameters . This study aims to estimate the mean and variance of rainfall data in several selected cities and regencies in West Sumatra.
Ferra Yanuar, Putri Trisna Sari, Yudiantri Asdi   +2 more
doaj   +1 more source

Bregman Cost for Non-Gaussian Noise [PDF]

, 2016
One of the tasks of the Bayesian inverse problem is to find a good estimate based on the posterior probability density. The most common point estimators are the conditional mean (CM) and maximum a posteriori (MAP) estimates, which correspond to the mean ...
Burger, Martin, Dong, Yiqiu, Sciacchitano, Federica   +2 more
core   +1 more source