Results 111 to 120 of about 8,843 (310)
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Empirical Bayes Derivative Estimates
Multivariate Behavioral Research, 2019 A dynamic system is a set of interacting elements characterized by changes occurring over time. The estimation of derivatives is a mainstay for exploring dynamics of constructs, particularly when the dynamics are complicated or unknown. The presence of measurement error in many social science constructs frequently results in poor estimates of ...
openaire +2 more sources
Advanced Science, EarlyView.We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
On the Stability of Bayes Estimators for Gaussian Processes. [PDF]
The Annals of Statistics, 1982 Consider a Gaussian signal process \(X=(X_ t)\) observed in the presence of an additive Gaussian noise process \(N=(N_ t)\) for t in [0,T]. The paper is concerned with the behaviour of the Bayes estimator \(\delta_ 0\) under departures from Gaussian law by the prior or noise processes. The problem of choosing a suitable contamination model is discussed.
openaire +2 more sources
An assessment of empirical Bayes and composite estimators for small areas [PDF]
We compare a set of empirical Bayes and composite estimators of the population means of the districts (small areas) of a country, and show that the natural modelling strategy of searching for a well fitting empirical Bayes model and using it for ...
Nicholas Longford
core
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
"Simultaneous estimation of normal precision matrices" [PDF]
This paper treats the problem of simultaneously estimating the precision matrices in multivariate normal distributions. A condition for improvement on the unbiased estimators of the precision matrices is derived under a quadratic loss function.
Hisayuki Tsukuma, Tatsuya Kubokawa
core
Bayes Estimators of the Cointegration Space [PDF]
, 2003 A neglected aspect of the otherwise fairly well developed Bayesian analysis of cointegration is the point estimation of the cointegration space. It is pointed out here that, due to the well known non-identification of the cointegration vectors, the ...
Villani, Mattias
core
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Mining housekeeping genes with a Naive Bayes classifier [PDF]
, 2006 The first author was supported by the Student Awards Agency for Scotland. The second author is supported by BBSRC grant BBS RC BB/D006473/1, and under the Advanced Knowledge Technologies (AKT) Interdisciplinary Research Collaboration (IRC), which is ...
Aitken, Stuart +6 more
core +1 more source