Results 51 to 60 of about 242,378 (342)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

DAMPE squib? Significance of the 1.4 TeV DAMPE excess

open access: yes, 2017
We present a Bayesian and frequentist analysis of the DAMPE charged cosmic ray spectrum. The spectrum, by eye, contained a spectral break at about 1 TeV and a monochromatic excess at about 1.4 TeV.
Fowlie, Andrew
core   +1 more source

Reporting and Interpretation in Genome-Wide Association Studies [PDF]

open access: yes, 2007
In the context of genome-wide association studies we critique a number of methods that have been suggested for flagging associations for further investigation.
Wakefield, Jon
core   +5 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Comparison between Bayes and Certainty Factor Method of Expert System in Early Diagnosis of Dengue Infection

open access: yesScientific Journal of Informatics, 2018
The development of existing artificial intelligence technology has been widely applied in detecting diseases using expert systems. Dengue Infection is one of the diseases that is commonly suffered by the community and may cause in death.
Eka Yuni Rachmawati   +2 more
doaj   +1 more source

Bayes Factors from Mixed Probabilities

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1978
Summary A new expression for a Bayes factor as a weighted average of conditional Bayes factors is given, resembling the familiar relation for a marginal probability as a weighted average of conditional probabilities. Interpretations are given for the three contexts of (i) the use of a non-sufficient statistic, (ii) inference for a simple
Dickey, J. M., Gunel, E.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

The mass distribution of Galactic double neutron stars

open access: yes, 2019
The conventional wisdom, dating back to 2012, is that the mass distribution of Galactic double neutron stars is well-fit by a Gaussian distribution with a mean of $1.33 M_\odot$ and a width of $0.09 M_\odot$.
Farrow, Nicholas   +2 more
core   +1 more source

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