Results 161 to 170 of about 2,095,528 (293)

Incremental refinement of relevance rankings: Balancing relevance depth and scope

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Delivering both relevant and topically diverse results is a key challenge in information retrieval (IR). This study introduces a hybrid method that incrementally refines rankings by combining probabilistic topic modeling (latent dirichlet allocation [LDA]) with citation‐based pennant retrieval grounded in Relevance Theory (RT), optimizing for ...
Müge Akbulut, Yaşar Tonta
wiley   +1 more source

Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes

Autism Research, EarlyView.
ABSTRACT Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of language, cognition, and social skills. Yet, marked variability in
I. Ilaridou, N. Kojovic, T. Chataing, K. Latrèche, F. Journal, S. Akhavan, C. Sandini, M. Schaer   +7 more
wiley   +1 more source

Brain complexity represents uncertainty in sequence learning and corroborates habituation deficit in Parkinson disease patients

Scientific Reports
Information processing is a core element of cognitive processes in the brain. Rooted in the idea postulated by John von Neumann that the stochasticity of neural operations might essentially be a reflection of the probabilistic nature of information, it ...
Mohammad Hossein Heidari Beni, Kamyab Hosseinpour, Mohammad Reza Seyednejad, Hamid Aghajan   +3 more
doaj   +1 more source

Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task‐Evoked Pupillary Responses

Autism Research, EarlyView.
ABSTRACT According to prevalent views, autistic individuals have a stronger tendency to allocate attention to details, as supported by reports of enhanced visual search performance. However, both the dynamics and the types of information involved in attentional guidance in autism are not fully understood.
Zainab Naaran, Amit Yashar
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, EarlyView.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

A Computational Theory of Mindfulness Based Cognitive Therapy from the "Bayesian Brain" Perspective. [PDF]

Front Psychiatry, 2020
Manjaly ZM, Iglesias S.
europepmc   +1 more source

Bayesian computational methods [PDF]

If, in the mid 1980?s, one had asked the average statistician about the difficulties of using Bayesian Statistics, his/her most likely answer would have been ?Well, there is this problem of selecting a prior distribution and then, even if one agrees on ...
Robert, Christian P.
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