Results 41 to 50 of about 294,457 (253)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Applied Sciences, 2019 Black carbon (BC) is an important component of particulate matter (PM) in urban environments. BC is typically emitted from gas and diesel engines, coal-fired power plants, and other sources that burn fossil fuel.
Martha A. Zaidan +3 more
doaj +1 more source
Independence and Bayesian updating methods [PDF]
Artificial Intelligence, 1986 Appears in Proceedings of the First Conference on Uncertainty in Artificial Intelligence (UAI1985)
openaire +4 more sources
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Frontiers in Genetics, 2016 Bacterial cold water disease (BCWD) causes significant economic losses in salmonid aquaculture, and traditional family-based breeding programs aimed at improving BCWD resistance have been limited to exploiting only between-family variation.
Roger L. Vallejo +8 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A Bayesian Approach to the Vertical Structure of the Disk of the Milky Way
The Open Journal of Astrophysics, 2020 This work investigates the vertical profile of the stars in the disk of the Milky Way. The models investigated are of the form sech2/n(nz/(2H)) where, setting α = 2/n, the three functions of the sequence α= 0, 1, 2 correspond to exponential, sech, and ...
Phillip S. Dobbie , Stephen J. Warren
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Warming Trends and Long-Range Dependent Climate Variability Since Year 1900: A Bayesian Approach
Frontiers in Earth Science, 2019 Temporal persistence in unforced climate variability makes detection of trends in surface temperature difficult. Part of the challenge is methodological since standard techniques assume a separation of time scales between trend and noise. In this work we
Eirik Myrvoll-Nilsen +3 more
doaj +1 more source