Results 31 to 40 of about 405,410 (243)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pregnancy-associated breast cancer: course, diagnosis and treatment

Акушерство, гинекология и репродукция
Pregnancy-associated breast cancer (ВС) is a rare pathology in the practice of an obstetrician-gynecologist and oncologist, which diagnostics is coupled to certain difficulties.
I. A. Salov, T. A. Basova, Yu. V. Mikhailova, I. I. Frolova   +3 more
doaj   +1 more source

White TESOL Instructors’ Engagement with Social Justice Content in an EAP Program: Teacher Neutrality as a Tool of White Supremacy

BC TEAL Journal, 2021
This study highlights the teaching practices of three white instructors—who addressed social justice issues in the context of their English for Academic Purposes (EAP) classes—to contextualize their pedagogy in relation to intersections of Whiteness and ...
Leah Mortenson
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Role of Contrast-Enhanced Imaging Methods in Breast Cancer Early Diagnostics and Treatment Planning

Вестник рентгенологии и радиологии
Оn March 27, 2023, а multidisciplinary Advisory Board meeting was held in Moscow with the participation of Е.V. Artamonova, Е.А. Busko, V.V. Didenko, А.D. Zikiryakhodzhaev, М.S. Karpova, G.Е. Kvetenadze, P.V. Krivorot’ko, М.L. Mazo, А.V.
I. Е. Tyurin, N. I. Rozhkova, E. V. Artamonova, E. A. Busko, V. V. Didenko, A. D. Zikiryakhodzhaev, M. S. Karpova, G. Е. Kvetenadze, P. V. Krivorot’ko, M. L. Mazo, A V. Petrovsky, О. S. Puchkova, S. V. Serebryakova, А. P. Bakulev   +13 more
doaj   +1 more source

Carving Out an Epistemological Space: EAL Teaching and Learning as a Field of Inquiry

BC TEAL Journal, 2022
The BC TEAL Journal continues to strengthen the field of English as an additional language (EAL) teaching and learning as a space for authors, reviewers, editors, and readers to come together in ways that underscore the knowledge creation, theory ...
Scott Roy Douglas
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

English-as-an-Additional-Language Employees’ Perspectives on Writing in the Workplace

BC TEAL Journal, 2020
This article presents study results on workplace writing from English-as-an-additional-language (EAL) employees’ perspectives, and shares findings about how educational institutions in British Columbia can better prepare EAL students to write in the ...
Jim Hu, Lachlan Gonzales
doaj   +1 more source