Results 121 to 130 of about 18,005 (233)

A Quantitative Systems Pharmacology Model of Human Leucine Metabolism

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Branched‐chain amino acids (BCAAs) are essential dietary components that humans cannot synthesize. Altered BCAA levels have been associated with biomarkers or potential risk factors in several metabolic disorders, including insulin resistance, type 2 diabetes, obesity, and cardiovascular disease.
J. Cody Herron, Anna Sher, Yingbo Ma, Elisabeth Roesch, Sebastian Miculța‐Câmpeanu, Christopher Rackauckas, Kevin J. Filipski, Rachel Roth Flach, Theodore R. Rieger, Cynthia J. Musante, Richard Allen   +10 more
wiley   +1 more source

Correspondence to letter to the editor on “Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunctionassociated steatotic liver disease” [PDF]

Clinical and Molecular Hepatology
Eiji Kakazu, Masaaki Mino, Tatsuya Kanto
doaj   +1 more source

Role of Branched‐Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models

Journal of Cachexia, Sarcopenia and Muscle
Background Osteosarcopenia, characterised by concurrent bone loss and muscle atrophy, presents a significant challenge in aging populations, particularly in postmenopausal women.
Geum‐Hwa Lee, Hwa‐Young Lee, Young‐Jae Lim, Se‐Woong Ko, Han‐Jung Chae, Sun‐Jung Yoon   +5 more
doaj   +1 more source

The appropriate dietary methionine content reduces deamination and gluconeogenesis in Chinese perch (Siniperca chuatsi)

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract This study evaluated the effects of different dietary methionine (Met) levels on the feeding, growth, and protein metabolism of Chinese perch, Siniperca chuatsi. Six diets containing graded levels of Met (0.88%, 1.11%, 1.68%, 2.02%, 2.27%, and 2.72%) were fed to fish (initial weight: 13.74 ± 0.12 g) for 8 weeks.
Xinyao Ji, Jiacheng Hu, Baoye Hao, Jinguo Chen, Binhua Niu, Yufei Zhang, Xu‐Fang Liang, Liwei Liu   +7 more
wiley   +1 more source

Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype

Advanced Science
The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs’ full effects on mammalian physiology remain ...
Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang   +15 more
doaj   +1 more source

A factorial multi‐layer analysis reveals non‐additive sulfur–iron interactions shaping metabolic and transcriptional responses in durum wheat

New Phytologist, Volume 252, Issue 1, Page 192-208, October 2026.
Working model of S‐dependent Fe stress integration in durum wheat. S availability acts as the main factor defining the metabolic and transcriptional state of the plant, whereas Fe mainly affects the intensity of these responses. This is particularly evident for OAS, methionine, citrate and asparagine, which accumulated most strongly under combined S ...
Eleonora Coppa, Mutsumi Watanabe, Moez Maghrebi, Giulia Quagliata, Alessandro Bruschini, Rainer Hoefgen, Youry Pii, Stefano Cesco, Gianpiero Vigani, Stefania Astolfi   +9 more
wiley   +1 more source

BCAT1 Enhances BCAA Production to Drive Myeloid Leukemia

, 2017
BCAT1 is highly expressed in BC-CML and AML and promotes BCAA production to drive tumor progression.

core   +1 more source

BCAA supplementation in patients undergoing resection for liver cancer [PDF]

, 2013
Sahlgrenska Academy at University of Gothenburg Department of Internal Medicine and Clinical Nutrition Abstract Title: BCAA supplementation in patients undergoing resection for liver cancer Author: Mikael Semaan and Viktor Sjöling Supervisor ...
Sjöling, Viktor, Semaan, Mikael
core  

The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance

Journal of Pharmacy & Pharmaceutical Sciences
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes.
Abdualrahman Mohammed Abdualkader, Abdualrahman Mohammed Abdualkader, Abdualrahman Mohammed Abdualkader, Qutuba G. Karwi, Gary D. Lopaschuk, Rami Al Batran, Rami Al Batran, Rami Al Batran   +7 more
doaj   +1 more source

Newly characterized mitochondrial BCAA transporter [PDF]

Nature Reviews Endocrinology, 2019
openaire   +2 more sources