A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
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BCG-Associated Complications Following Delayed Vaccination in Infants in Saudi Arabia: A Retrospective Cohort Study. [PDF]
Alnajjar LI +10 more
europepmc +1 more source
BCG-YOLO: an efficient YOLO-based framework for multi-class blood cell detection in microscopic images. [PDF]
Chen Z +7 more
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Trained Immunity in Childhood Vaccination
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai +2 more
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Molecular Classifications and Candidate Biomarkers for Personalizing BCG Therapy in Non-Muscle-Invasive Bladder Cancer. [PDF]
Bilyalov A +5 more
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Symptom‐guided reduction of BCG dwell time: findings from the north‐REG randomized trial
Objectives To evaluate the impact of personalized dwell‐time (DT) reductions on symptom prevalence and systemic toxicities in patients undergoing Bacillus Calmette–Guérin (BCG) instillation for non‐muscle invasive bladder cancer (NMIBC). Methods Within a multinational randomized controlled trial (North‐REG Dwell Time Study [NCT04701151]), 225 patients ...
Lene Munk +15 more
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First‐in‐human outpatient management of recurrent NMIBC with the Multi4 instrument
Objectives To evaluate the feasibility, safety and diagnostic performance of outpatient management of recurrent non‐muscle‐invasive bladder cancer (NMIBC) under local anaesthesia using the Multi4 instrument, a series of preclinical studies were performed followed by a first‐in‐human clinical investigation.
Miden Melle‐Hannah +4 more
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Cholesterol 25-Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin-12-Interleukin-2 Axis in BCG-Vaccinated Mice. [PDF]
Kim H +6 more
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ABSTRACT Over the last decade, policy actors have produced a surge of “future of work” reports that reimagine workers through the dual logics of digitalization and human capital. Drawing on 25 policy documents (WEF, World Bank, OECD, EU, and major consultancies) and combining Bacchi and Goodwin's WPR approach with decolonial feminist theory, this paper
Muneeb Ul Lateef Banday
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Advancing Tuberculosis Vaccination: Immunological Insights and Emerging Strategies for Improved Protection. [PDF]
Zhang Z +7 more
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