Results 51 to 60 of about 1,169 (119)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

MRI and clinical features of maple syrup urine disease: preliminary results in 10 cases

Diagnostic and Interventional Radiology, 2017
PURPOSE:We aimed to evaluate the magnetic resonance imaging (MRI) and clinical features of maple syrup urine disease (MSUD).METHODS:This retrospective study consisted of 10 MSUD patients confirmed by genetic testing.
Ailan Cheng, Lianshu Han, Yun Feng, Huimin Li, Rong Yao, Dengbin Wang, Biao Jin   +6 more
doaj   +1 more source

Plasma Branched‐Chain Amino Acids Are Associated With Gut Dysbiosis and Inflammatory Markers in Type 2 Diabetes Mellitus

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Background Branched‐chain amino acids (BCAAs) are established biomarkers of insulin resistance. However, their relationship with gut microbiota composition, dietary patterns, and systemic inflammation in African populations with Type 2 diabetes mellitus (T2DM) remains unexplored.
Muhammad Lawal Jidda, Jafaru Muhammad Bunza, Halima Hussaini Salihu, Umar Asiya Imam, Muhammad Kabiru Dallatu, Ogunwale Kolawole Ayobami, Yusuf Habeb Demilola, Giwa Jamiah Ikeoluwa, Oladele Blessing Shina, Aliyu Maimuna Umar, Idris Safiyya Aminu, Jiong Yu   +11 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Analysis of Microbial Community Structure and Functional Genes for Volatile Flavor in Stinky Tofu

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study integrated metagenomics to decipher the core microbiota (e.g., Pseudomonas, Acinetobacter, Enterobacter) and functional genes governing volatile flavor biosynthesis in stinky tofu. Key enzymes like glycoside hydrolases and alcohol dehydrogenases catalyzed carbohydrate and amino acid metabolism, generating characteristic compounds such as ...
Aiguo Luo, Lifang Liu, Shengli Shi, Xiaoxia Liu, Bianfang Hu   +4 more
wiley   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Foodomics in Diabetes Management: A New Approach

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review also efforts to show the promise of personalized nutritional guidance based on an individual's own genetic and metabolic profile, which could lead to better glycaemic control and fewer diabetes‐related complications. Concerns about foodomics in hazard assessment, food safety, and the determination of bioactive substances that can be ...
Sammra Maqsood, Muhammad Tayyab Arshad, Ali Ikram, Hatem A. Al‐Aoh, Kodjo Théodore Gnedeka   +4 more
wiley   +1 more source

Adipocytes Are the Only Site of Glutamine Synthetase Expression Within the Lactating Mouse Mammary Gland

Current Developments in Nutrition
Background: Glutamine in milk is believed to play an important role in neonatal intestinal maturation and immune function. For lactating mothers, glutamine utilization is increased to meet the demands of the enlarged intestine and milk production ...
Huyen Le, Mai Nguyen, Helena Emilia CCC Manso, Michelle D Wang, Malcolm Watford   +4 more
doaj   +1 more source

Exploring molecular spectrum in thai patients with maple syrup urine disease: unveiling a common variant

Orphanet Journal of Rare Diseases
Background Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder caused by variants in any of the following genes: BCKDHA, BCKDHB, and DBT gene.
Panisara Lakkhana, Thipwimol Tim-Aroon, Arthaporn Khongkraparn, Saisuda Noojarern, Parith Wongkittichote, Khunton Wichajarn, Chulaluck Kuptanon, Boonchai Boonyawat, Kanya Suphapeetiporn, Karn Wejaphikul, GoHun Seo, Duangrurdee Wattanasirichaigoon   +11 more
doaj   +1 more source

Two novel mutations in the BCKDHB gene that cause maple syrup urine disease

Pediatrics and Neonatology, 2018
Background: Maple syrup urine disease (MSUD) is a rare metabolic disorder of autosomal recessive inheritance caused by decreased activity of branched-chain α-ketoacid dehydrogenase complex (BCKD). Mutations in the three genes (BCKDHA, BCKDHB and DBT) are
Bingjuan Han, Bingchao Han, Bin Guo, Yingxia Liu, Zhiyang Cao   +4 more
doaj   +1 more source