Results 11 to 20 of about 219,243 (185)

The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line [PDF]

Middle East Journal of Cancer, 2022
Background: A high number of human breast cancers overexpress the murine double minute (MDM2) gene which blocks the p53 protein which plays an important role in arresting the cell growth.
Tahereh Kalantari, Bahram Mohseni-Aghdam, Fatemeh Nasri, Gholamhossein Tamaddon, Mohsen Kalantari   +4 more
doaj   +1 more source

Bcl-2-associated transcription factor 1 interacts with fragile X-related protein 1 [PDF]

Acta Biochimica et Biophysica Sinica, 2014
The absence of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), which is the leading cause of hereditary mental retardation. Fragile X-related protein 1 (FXR1P), which plays an important role in normal muscle development, is one of the two autosomal paralogs of FMRP.
Yun, Ma, Changbo, Wang, Binyuan, Li, Lingxue, Qin, Jiao, Su, Manjun, Yang, Shuya, He   +6 more
openaire   +2 more sources

Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein. [PDF]

PLoS ONE, 2013
The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B Göran Karlsson, Gerhard Gröbner   +5 more
doaj   +1 more source

BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. [PDF]

PLoS ONE, 2014
An enhanced anti-apoptotic capacity of tumor cells plays an important role in the process of breakpoint cluster region/Abelson tyrosine kinase gene (BCR/ABL)-independent imatinib resistance. We have previously demonstrated that brain expressed X-linked 1
Qian Xiao, Yeting Hu, Yue Liu, Zhanhuai Wang, Haitao Geng, Lifeng Hu, Dengyong Xu, Ke Wang, Lei Zheng, Shu Zheng, Kefeng Ding   +10 more
doaj   +1 more source

Bcl-2-Associated X Protein Is the Main Mediator of Manumycin A-Induced Apoptosis in Anaplastic Thyroid Cancer Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2005
We previously demonstrated that the combination of paclitaxel and manumycin A, a farnesyltransferase inhibitor, enhanced apoptosis of anaplastic thyroid cancer (ATC) cells. However, the mechanism of the manumycin-induced apoptosis is not fully understood.
Jingxuan, Pan, Huizhi, Huang, Lily, Sun, Bingliang, Fang, Sai-Ching Jim, Yeung   +4 more
openaire   +2 more sources

Gene expression profiling ofliver X receptor αandBcl-2-associated X proteinin experimental transection spinal cord-injured rats [PDF]

The Journal of Spinal Cord Medicine, 2013
Study of molecular responses to central nervous system injury would be helpful for controlling the harmful pathways post-injury and triggering the useful pathways required for the treatment of injury.To investigate the expression level of liver X receptor α (LXRα) which has anti-inflammatory effects and pro-apoptotic Bcl-2-associated X protein (Bax ...
Esmat, Mohammadi, Kamran, Ghaedi, Abolghasem, Esmailie, Soheila, Rahgozar   +3 more
openaire   +2 more sources

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Relative transcript level of BMP15, BAX and CASP3 with qRT-PCR in vitrified equine immature cumulus-oocytes complexes

Semina: Ciências Agrárias, 2022
Research focused on female gamete vitrification has increased attention to develop a reliable cryopreservation method to preserve immature equine oocytes.
Mauro Flores Polenz, Gabriel Ribas Pereira, Vitor Braga Rissi, Kalyne Bertolin, Paulo Bayard Gonçalves, Geovani Celso Augusto, Sandra Mara Fiala Rechsteiner   +6 more
doaj   +1 more source

Oxidative Stress-Induced Unscheduled CDK1–Cyclin B1 Activity Impairs ER–Mitochondria-Mediated Bioenergetic Metabolism

Cells, 2021
Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation,
Jan-Gowth Chang, Ni Tien, Yi-Chih Chang, Meng-Liang Lin, Shih-Shun Chen   +4 more
doaj   +1 more source

Royal Jelly Feeding as a Main Inducer of Bcl-2-associated X Protein in the Peripheral Blood Immune Cells of Patients With Chronic Hepatitis B

Avicenna Journal of Clinical Microbiology and Infection, 2022
Aim: Chemokines, cytokines, and their related molecules play crucial roles in the fight against the hepatitis B virus (HBV) and its related complications. Royal jelly (RJ) is considered an immunomodulatory factor for humans. This clinical trial study aimed to explore the RJ effects on the relative expression of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX,
Morteza Bahaaldin-Beygi, Ashraf Kariminik, Mohammad Kazemi Arababadi   +2 more
openaire   +1 more source