Results 41 to 50 of about 36,627,339 (183)

Reproductive status of male rat offspring following exposure to methamphetamine during intrauterine life: An experimental study

International Journal of Reproductive BioMedicine, 2023
Background: Methamphetamine abuse during pregnancy is associated with maternal and fetal adverse outcomes. Methamphetamine induces reproductive damage in adults; however, its effect has not been studied during pregnancy.
Zahra Khoshgoftar Some Saraii, Soroush Dianaty, Fatemeh Rouhollah, Nayereh Zare, Batool Ghorbani Yekta   +4 more
doaj   +1 more source

Impact of neurotrophic factors combination therapy on retinitis pigmentosa

Journal of International Medical Research, 2020
Objective We aimed to determine the location of neurotrophic receptors tropomyosin receptor kinase (Trk)B, TrkC, and ciliary neurotrophic factor receptor (CNTFR)α in the retina of retinal degeneration ( rd ) mice and to explore the dynamic changes of B ...
Xiaobei Yin, Ting He, Rui Chen, Hui Cui, Genlin Li   +4 more
doaj   +1 more source

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

Virulence, 2019
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR).
Parvaneh Mehrbod, Sudharsana R. Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K. M. Glover, Affan A. Sher, Kevin M. Coombs, Saeid Ghavami   +10 more
doaj   +1 more source

Alpha-pinene alleviates CCl4-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory ...
Fatemeh Noroozi, Masoumeh Asle Rousta, Rahim Amini, Zeinab Sahraeian   +3 more
doaj   +1 more source

Dissecting the pathways of tumour escape: " question of life and death?" Dissecando os caminhos de escape do tumor: "uma questão de vida e morte?"

Anais Brasileiros de Dermatologia, 2010
Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction
Georgi Tchernev, Pietro Nenoff
doaj   +1 more source

BCL-2-regulated apoptosis.

, 2023
(A) The BCL-2-regulated apoptotic pathway involves the following proteins pro-survival BCL-2 proteins, pro-apoptotic BH3-only proteins, and apoptosis effectors BAX/BAK proteins. Lines indicate interactions between molecules. (B) In healthy cells, the pro-
Nathaniel Chien (14636956), Hyun Joo (199982), Jennifer Yi (14636950), Shivarni Patel (14636959), Vivian Kellner (14636953), Jerry Tsai (199995), Zaina Chaban (14636962)   +6 more
core   +1 more source

Effect of cinnamaldehyde on Bax/Bak and apoptosis of vascular endothelial cells in diabetic ulcers

陆军军医大学学报
Objective To investigate the effects of cinnamic aldehyde (CA) on Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak) in vascular endothelial cells of diabetic ulcer wound tissues, as well as on cell apoptosis.
JIN Zheyu, XIE Chenlei , FAN Xinqi
doaj   +1 more source

Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats

Brazilian Journal of Cardiovascular Surgery
Objective: This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms. Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and ...
Longfei Wang, Yong Li, Shenglan Lin, Zhiqiang Pu, Haiping Li, Zhili Tang   +5 more
doaj   +1 more source

Effect of Icariin on apoptosis and expression of Fas, Fas ligand, B cell lymphoma, and Bcl-2-associated X protein in CD4 + T lymphocytes from patients with ankylosing spondylitis

Journal of Traditional Chinese Medicine, 2017
To investigate the effects of icariin on apoptosis and the expression of Fas, Fas ligand (FasL), B cell lymphoma (Bcl-2), and Bcl-2-associated X protein (Bax) in CD4＋ T lymphocytes from patients with ankylosing spondylitis.Primary cultures of peripheral blood CD4+ T lymphocytes were established and treated with icariin at high, medium, and low doses (0.
Hailong, Wang, Quan, Jiang, Xinghua, Feng   +2 more
openaire   +2 more sources

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source