Results 21 to 30 of about 36,627,339 (183)

A-Type Cinnamon Procyanidin Oligomers Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity in Mice Through Inhibiting the P38 Mitogen-Activated Protein Kinase/P53/BCL-2 Associated X Protein Signaling Pathway [PDF]

The Journal of Nutrition, 2020
Parkinson's disease (PD) is a common neurodegenerative disorder. Cinnamon procyanidin oligomers (CPOs) are flavonoids with many claimed health benefits.This study aimed to elucidate the neuroprotection of A-type CPOs (CPO-A) and the underlying mechanisms in cultured cell and animal models of PD.Thirty male mice (C57BL/6, 9-wk old) were assigned to 3 ...
Qi, Xu, Ziyu, Chen, Borong, Zhu, Gaorui, Wang, Qi, Jia, Yiming, Li, Xiaojun, Wu   +6 more
openaire   +2 more sources

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells

Toxins, 2023
Emodin, an emerging mycotoxin, is known to be hepatotoxic, but its mechanism remains unclear. We hypothesized that emodin could induce endoplasmic reticulum (ER) stress through the inositol-requiring enzyme 1 alpha (IRE1α)–X-box-binding protein 1 (XBP1 ...
Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun   +3 more
doaj   +1 more source

Screening of BCL-2 associated X protein gene polymorphism associated with scrotal hernia in domesticated swine using polymerase chain reaction-restriction fragment length polymorphism [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
Objective This study was conducted to screen scrotal hernia in domesticated swine from selected breeders in the Philippines. This defect is associated with a cytosine to thymine mutation in the BCL-2 associated X protein (BAX) gene of swine. Methods Genetic screening was done by DNA extraction followed by amplification and digestion using polymerase ...
Jessica G. Manalaysay, Nathaniel D. Antonio, Ralph Lorenz R. Apilado, Joseph F. Bambico, Claro N. Mingala   +4 more
openaire   +3 more sources

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Teo, K., Traynor, P., Mukherjee, R., Edwards, J., Gemmell, L.   +4 more
core   +1 more source

Possible Protective Effects of Lutein against Ciprofloxacin Induced Bone Marrow Toxicity in Rats

Iraqi Journal of Pharmaceutical Sciences, 2021
Ciprofloxacin, which is a second generation of fluoroquinolone and one of the most effective and widely used drugs within fluoroquinolone. Unfamiliar adverse effects of ciprofloxacin such as bone marrow (BM) suppression, thrombocytopenia, anemia ...
Alaa R. Khudhair, Nada N Al-Shawi
doaj   +1 more source

Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members. [PDF]

, 2013
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is an open question.
Ali Hosseini (383134), Roberto Quesada (383137), Vanessa Soto-Cerrato, Quesada, Roberto, Guallar, Victor, Hossein, Ali, Victor Guallar (218011), Espona Fiedler, Margarita, Hosseini, Seyed Ali, Vanessa Soto-Cerrato (383136), Guallar Victor, Victor Guallar, Soto-Cerrato Vanessa, Ali Hosseini, Soto Cerrato, Vanessa, Hosseini Ali, Quesada Roberto, Pérez-Tomás Ricardo, Quesada Pato, Roberto, Margarita Espona-Fiedler, Margarita Espona-Fiedler (383135), Pérez Tomás, Ricardo E., Espona-Fiedler Margarita, Ricardo Pérez-Tomás (383138), Ricardo Pérez-Tomás, Pérez Tomás, Ricardo, Roberto Quesada   +26 more
core   +2 more sources

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source

Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

The Journal of Clinical Investigation, 2023
The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic lymphocytic leukemia (CLL); however, resistance may develop over time.
Stephen Jun Fei Chong, Fen Zhu, Olga Dashevsky, Rin Mizuno, Jolin X.H. Lai, Liam Hackett, Christine E. Ryan, Mary C. Collins, J. Bryan Iorgulescu, Romain Guièze, Johany Penailillo, Ruben Carrasco, Yeonjoo C. Hwang, Denise P. Muñoz, Mehdi Bouhaddou, Yaw Chyn Lim, Catherine J. Wu, John N. Allan, Richard R. Furman, Boon Cher Goh, Shazib Pervaiz, Jean-Philippe Coppé, Constantine S. Mitsiades, Matthew S. Davids   +23 more
doaj   +1 more source

Synergistic impacts of rifampicin and doxorubicin against thioacetamide-induced hepatocellular carcinoma in rats

Liver Research, 2023
Background and aims: Combination therapy is a promising new strategy that has been proposed to increase the efficacy of cancer treatment. We aimed to investigate the anti-cancer activity of rifampicin monotherapy and its combination with doxorubicin ...
Zahraa R. Elshahawy, Entsar A. Saad, Rana R. El-Sadda   +2 more
doaj   +1 more source

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source