Results 11 to 20 of about 182,114 (270)

Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

The Journal of Clinical Investigation, 2023
The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic lymphocytic leukemia (CLL); however, resistance may develop over time.
Stephen Jun Fei Chong, Fen Zhu, Olga Dashevsky, Rin Mizuno, Jolin X.H. Lai, Liam Hackett, Christine E. Ryan, Mary C. Collins, J. Bryan Iorgulescu, Romain Guièze, Johany Penailillo, Ruben Carrasco, Yeonjoo C. Hwang, Denise P. Muñoz, Mehdi Bouhaddou, Yaw Chyn Lim, Catherine J. Wu, John N. Allan, Richard R. Furman, Boon Cher Goh, Shazib Pervaiz, Jean-Philippe Coppé, Constantine S. Mitsiades, Matthew S. Davids   +23 more
doaj   +2 more sources

Screening of BCL-2 associated X protein gene polymorphism associated with scrotal hernia in domesticated swine using polymerase chain reaction-restriction fragment length polymorphism. [PDF]

Asian-Australas J Anim Sci, 2017
Objective This study was conducted to screen scrotal hernia in domesticated swine from selected breeders in the Philippines. This defect is associated with a cytosine to thymine mutation in the BCL-2 associated X protein (BAX) gene of swine. Methods Genetic screening was done by DNA extraction followed by amplification and digestion using polymerase ...
Manalaysay JG, Antonio ND, Apilado RL, Bambico JF, Mingala CN.   +4 more
europepmc   +5 more sources

Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein. [PDF]

PLoS ONE, 2013
The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B Göran Karlsson, Gerhard Gröbner   +5 more
doaj   +2 more sources

Baicalin extracted from Huang qin (Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9

Journal of Traditional Chinese Medicine, 2017
Objective To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.
Hongwei Wang, Hailong Li, Chenglin Qin, Luo Jun, Gu Jing, Huping Wang, Hongyan Wu, Xu Yan   +7 more
semanticscholar   +3 more sources

Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

Mediators of Inflammation, 2018
During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling.
Mayumi Iguchi, Miki Hiroi, Haruhide Kanegae, Yoshihiro Ohmori   +3 more
doaj   +2 more sources

Potential Cytotoxic Activity of Galegine on Human Melanoma Cells [PDF]

Research Journal of Pharmacognosy, 2022
Background and objectives: Melanoma, the most lethal type of skin cancer, has a high recurrence rate within one year in melanoma patients following treatment by chemotherapy or immunotherapy.
Mohammad Hassan Arjmand, Hamed Sabri, Abolfazl Maghrouni, Elmira Zarei, Massoumeh Hotelchi, Amir Reza Afshari*   +5 more
doaj   +1 more source

The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line [PDF]

Middle East Journal of Cancer, 2022
Background: A high number of human breast cancers overexpress the murine double minute (MDM2) gene which blocks the p53 protein which plays an important role in arresting the cell growth.
Tahereh Kalantari, Bahram Mohseni-Aghdam, Fatemeh Nasri, Gholamhossein Tamaddon, Mohsen Kalantari   +4 more
doaj   +1 more source

Bcl-2-associated transcription factor 1 interacts with fragile X-related protein 1 [PDF]

Acta Biochimica et Biophysica Sinica, 2014
The absence of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), which is the leading cause of hereditary mental retardation. Fragile X-related protein 1 (FXR1P), which plays an important role in normal muscle development, is one of the two autosomal paralogs of FMRP.
Yun, Ma, Changbo, Wang, Binyuan, Li, Lingxue, Qin, Jiao, Su, Manjun, Yang, Shuya, He   +6 more
openaire   +2 more sources

Royal Jelly Feeding as a Main Inducer of Bcl-2-associated X Protein in the Peripheral Blood Immune Cells of Patients With Chronic Hepatitis B

Avicenna Journal of Clinical Microbiology and Infection, 2022
Aim: Chemokines, cytokines, and their related molecules play crucial roles in the fight against the hepatitis B virus (HBV) and its related complications. Royal jelly (RJ) is considered an immunomodulatory factor for humans. This clinical trial study aimed to explore the RJ effects on the relative expression of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX,
Morteza Bahaaldin-Beygi, Ashraf Kariminik, Mohammad Kazemi Arababadi   +2 more
openaire   +1 more source

BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. [PDF]

PLoS ONE, 2014
An enhanced anti-apoptotic capacity of tumor cells plays an important role in the process of breakpoint cluster region/Abelson tyrosine kinase gene (BCR/ABL)-independent imatinib resistance. We have previously demonstrated that brain expressed X-linked 1
Qian Xiao, Yeting Hu, Yue Liu, Zhanhuai Wang, Haitao Geng, Lifeng Hu, Dengyong Xu, Ke Wang, Lei Zheng, Shu Zheng, Kefeng Ding   +10 more
doaj   +1 more source