Results 191 to 200 of about 232,551 (308)

Phenylethanoid Glycosides in Cistanches: Chemistry, Pharmacokinetic, and Antitumor Properties

Food Frontiers, EarlyView.
This review systematically summarizes the representative PhGs found in CH species, their pharmacokinetic parameters, and primary metabolites in humans and rats. Additionally, it examines the antitumor activities of PhGs in CH and their associated signaling pathways against various malignancies.
Jie Li, Xin‐yue Cao, Jun‐lin Lv, He‐meng Zhang, Qing‐yue Liang, Yu‐shan Ren, Jun Tian, Gui‐cheng Dong   +7 more
wiley   +1 more source

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Head &Neck, Volume 47, Issue 8, Page 2101-2113, August 2025.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells.
Kimberly Wei, Brianna L. Hill, Joel C. Thompson, Zoey A. Miller, Arielle Mueller, Robert J. Lee, Ryan M. Carey   +6 more
wiley   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Apoptosis regulators of the Bcl‐2 family play a key role in chemoresistance of cholangiocarcinoma organoids

International Journal of Cancer, EarlyView.
What's New? Poor prognosis in cholangiocarcinoma (CCA) is attributed to late diagnosis and intrinsic chemoresistance. In particular, resistance mechanisms that suppress apoptosis limit the effectiveness of gemcitabine‐based regimens, which remain the standard treatment.
Wunan Mi, Gilles S. van Tienderen, Shaojun Shi, Amy Broeders, Kathryn Monfils, Henk P. Roest, Luc J. W. van der Laan, Monique M. A. Verstegen   +7 more
wiley   +1 more source

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source

Soyasaponin and vertical microbial transmission: Maternal effect on the intestinal development and health of early chicks

iMeta, EarlyView.
This study investigates the vertical transmission of maternal microbiota in chickens and how it is modulated by maternal soyasaponin supplementation. Using a model spanning the reproductive tract, egg components, and developing chicks, we show that maternal gut and reproductive microbiota, including Bifidobacterium adolescentis (B.
Mingkun Gao, Shu Chen, Hao Fan, Peng Li, Aiqiao Liu, Dongli Li, Xiaomin Li, Yongfei Hu, Guofeng Han, Yuming Guo, Zengpeng Lv   +10 more
wiley   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

Paeoniflorin induces G2/M cell cycle arrest and caspase-dependent apoptosis through the upregulation of Bcl-2 X-associated protein and downregulation of B-cell lymphoma 2 in human osteosarcoma cells

, 2018
Libin Jin, Jian Zhu, Chengzhen Liang, Li-jiang Tao, Bing Liu, Wei Yu, Han Zou, Junjie Wang, Huimin Tao   +8 more
openalex   +2 more sources

Ligustrazine suppresses neuron apoptosis via the Bax/Bcl‐2 and caspase‐3 pathway in PC12 cells and in rats with vascular dementia

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2018
T. Zhao, Yingxue Fu, Haopeng Sun, Xiaoquan Liu   +3 more
semanticscholar   +1 more source