Results 231 to 240 of about 213,161 (287)

Synergistic cytotoxicity of recombinant IGFBP-3 and cisplatin in HPV18-positive HeLa cells <i>via</i> NF-κB inflammatory modulation. [PDF]

Res Pharm Sci
Arab H, Shokrzadeh M, Mousavi T, Mofid MR.   +3 more
europepmc   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Co-Exposure to Aflatoxin B1 and Patulin Induces Hepatic Injury in Mice and HepG2 Cells by Activating Oxidative Stress and Apoptosis. [PDF]

Toxins (Basel)
Liu Y, Lei S, Peng Y, Li Y, Chen X, Xu X, Mao S.   +6 more
europepmc   +1 more source

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source

Targeting the PBX1-BCL2L1 axis as a therapeutic strategy in colorectal cancer. [PDF]

Cell Death Discov
Lin H, Su T, Liu Y, Deng R, Li J, Lin X, Ke Q, Luo Y, Meng L, Liang B, Song X, Huang D, Xie L.   +12 more
europepmc   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes. [PDF]

Signal Transduct Target Ther
Aboelella NS, Park R, Tang E, Asby N, Ho JD, Pan T, Wang S, Xie L, Kline JP, Riedell PA, Huang J, LaBelle JL.   +11 more
europepmc   +1 more source

Mechanistic investigation of artesunate against head and neck squamous cell carcinoma through network pharmacology and experimental validation. [PDF]

Discov Oncol
Wei L, He D, Jia L, Mo H, Ma H, Wu X, Yuan W.   +6 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation. [PDF]

Biochem Soc Trans
De Pinto V, Battiato G, Conti-Nibali S, Cubisino SAM.   +3 more
europepmc   +1 more source