Results 251 to 260 of about 232,551 (308)

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection

Aging Cell, EarlyView.
Genetic or pharmacological depletion of senescent cells during influenza A virus infection led to complete recovery of the airway epithelium, indicating a marked acceleration of the epithelial repair process. Targeting senescent cells may represent a new preventive therapeutic option to reduce post‐influenza chronic lung damage.
Larissa Lipskaia, Lou Delval, Valentin Sencio, Emmanuelle Born, Séverine Heumel, Amal Houssaini, Clara Valentin, Stefano Raviola, Lucie Deruyter, Fabiola Silva Angulo, Vincent Gros, Elisabeth Marcos, Shariq Abid, Mira Goekyildirim, Vanessa Contreras, Jean Michel Flaman, Roger Le Grand, Ronan Le Goffic, David Bernard, Serge Adnot, François Trottein   +20 more
wiley   +1 more source

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Aging Cell, EarlyView.
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu, Di Fan, Hai‐peng Wu, Xiao‐yi Hu, Qiu‐li He, Xin‐miao Wu, Cui‐na Shi, Jian‐jun Yang, Mu‐huo Ji   +8 more
wiley   +1 more source

The apoptosis geneBCL-Xsplice isoforms have opposing effects in diabetic kidney disease: potential treatment target and prognostic value

Stevens M, Ayine ML, Gooding K, Shore A, Marqueti P, Oltean S.   +5 more
europepmc   +1 more source

Protein Kinase C Epsilon Overexpression Protects the Heart Against Doxorubicin-Induced Cardiotoxicity Via Activating SIRT1. [PDF]

Cardiovasc Toxicol
Liu D, Wang C, Chen Y, Huang X, Wen Y, Duan S, Cai Y, Li X, He J, Han K, Li T, Li Y, Xia Z.   +12 more
europepmc   +1 more source

Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Glaucoma is an optic neuropathy caused by neurodegenerative loss of retinal ganglion cells (RGC). Mechanisms that contribute to RGC death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li).
Tomas Hajek, Orestes Forlenza, Marcelo Nicolela, Ann‐Eva Christensen, Henrik Vorum, René Ernst Nielsen   +5 more
wiley   +1 more source

Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case. [PDF]

Front Oncol
Chen H, Yu M, Chang Z, Li Y, Fan L, Shang D, Zhang H.   +6 more
europepmc   +1 more source

Modulation of Cellular, Molecular, and Humoral Responses by PQ Grass 27,600 SU for the Treatment of Seasonal Allergic Rhinitis: A Randomised Double Blind Placebo Control Exploratory Field Study

Allergy, EarlyView.
The aim of the study is to interrogate immunological mechanisms induced by PQ Grass conventional and extended regimens. A short‐course pre‐seasonal subcutaneous injection of PQ Grass is effective in inducing immune tolerance by generating functional blocking antibodies and modulating T cell compartments.
Janice A. Layhadi, Sviatlana Starchenka, Pieter‐Jan De Kam, Elizabeth Palmer, Lily Y. D. Wu, Sean T. Keane, William T. Fulton, Prista Hikmawati, Xun Meng, Paulina Filipaviciute, Anna Cutrina Pons, Kemi Oluwayi, Katarzyna Lis, Oliver Armfield, Murray A. Skinner, Matthew D. Heath, Simon J. Hewings, Matthias F. Kramer, Mohamed H. Shamji   +18 more
wiley   +1 more source

Gardenia-derived extracellular vesicles exert therapeutic effects on dopaminergic neuron apoptosis-mediated Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Chen W, Wang H, Ye X, Hao X, Yan F, Wu J, Li D, Wang Y, Xu L.   +8 more
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source