Results 21 to 30 of about 232,551 (308)

Baicalin extracted from Huang qin ( Radix Scutellariae Baicalensis ) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9

Journal of Traditional Chinese Medicine, 2017
To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.
Hongwei Wang, Xiaojun Liu, Chen Feng qin, Luo Jun, Gu Jing, Huping Wang, Hongyan Wu, Xu Guang Yan   +7 more
openalex   +4 more sources

Critical Roles of VEGFR1, VEGFR2, VEGFR3, BAX, and BCL-2 in the Pathogenesis of Varicose Veins: Unveiling Molecular Mechanisms [PDF]

American Journal of Men's Health
Varicocele is characterized by the abnormal dilation of veins within the testicular pampiniform plexus, contributing to inflammation, pain, and infertility in males.
Mehdi Abedinzadeh, Alireza Nazari, Seraj-Aldin Vahidi, Soheila Pourmasumi, Hossein Khorramdelazad   +4 more
doaj   +2 more sources

Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

Mediators of Inflammation, 2018
During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling.
Mayumi Iguchi, Miki Hiroi, Haruhide Kanegae, Yoshihiro Ohmori   +3 more
doaj   +2 more sources

The Anticancer Effect of Genistein Through Enhancing PERK Signaling and Suppressing the IRE1α-XBP1 Axis in Canine Mammary Gland Tumor Cells [PDF]

Animals
Genistein, a natural isoflavone, exerts anticancer effects on human breast cancer cells by modulating the unfolded protein response (UPR). However, the effect of genistein on UPR in canine mammary gland tumor (CMT) cells remains unknown.
Ye-Ji Jang, Min-Jae Yoo, Hyuk Jang, Jun Song, Sang-Youel Park, Jawun Choi, Jae-Won Seol   +6 more
doaj   +2 more sources

Juglone Induces Michigan Cancer Foundation-7 Human Breast Cancer Cells Apoptosis through Bcl-2-Associated X protein/B-cell lymphoma/leukemia-2 Signal Way

Pharmacognosy Magazine, 2019
Background: Juglone is a natural pigment, which has a cytotoxic effect against tumor cells. However, its cytotoxicity to human breast cancer cells (Michigan Cancer Foundation-7 [MCF7]) has not been demonstrated. Objective: The objective was to observe the effect of Juglone on the protein expression of caspase-3, 9 in the apoptosis of Human Breast ...
Suhong Sun, Qing Luo, Kang Hu, Fang Chen, Feng-Jiao Gan, Yuanxiu Leng, Xumei Chen   +6 more
openalex   +3 more sources

Potential Cytotoxic Activity of Galegine on Human Melanoma Cells [PDF]

Research Journal of Pharmacognosy, 2022
Background and objectives: Melanoma, the most lethal type of skin cancer, has a high recurrence rate within one year in melanoma patients following treatment by chemotherapy or immunotherapy.
Mohammad Hassan Arjmand, Hamed Sabri, Abolfazl Maghrouni, Elmira Zarei, Massoumeh Hotelchi, Amir Reza Afshari*   +5 more
doaj   +1 more source

The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line [PDF]

Middle East Journal of Cancer, 2022
Background: A high number of human breast cancers overexpress the murine double minute (MDM2) gene which blocks the p53 protein which plays an important role in arresting the cell growth.
Tahereh Kalantari, Bahram Mohseni-Aghdam, Fatemeh Nasri, Gholamhossein Tamaddon, Mohsen Kalantari   +4 more
doaj   +1 more source

Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts [PDF]

, 2023
The growth of ameloblastomas (odontogenic tumours) and odontogenic keratocyst (OKC) (developmental cyst) is associated with the expression of proteins related to cell survival and apoptosis.
Chimenos Küstner, Eduardo, Escobar, Enrico, Gómez-Valenzuela, Fernán, Perez Tomas, Ricardo Enrique, Peñafiel, Cristián   +4 more
core   +1 more source

BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. [PDF]

PLoS ONE, 2014
An enhanced anti-apoptotic capacity of tumor cells plays an important role in the process of breakpoint cluster region/Abelson tyrosine kinase gene (BCR/ABL)-independent imatinib resistance. We have previously demonstrated that brain expressed X-linked 1
Qian Xiao, Yeting Hu, Yue Liu, Zhanhuai Wang, Haitao Geng, Lifeng Hu, Dengyong Xu, Ke Wang, Lei Zheng, Shu Zheng, Kefeng Ding   +10 more
doaj   +1 more source

Relative transcript level of BMP15, BAX and CASP3 with qRT-PCR in vitrified equine immature cumulus-oocytes complexes

Semina: Ciências Agrárias, 2022
Research focused on female gamete vitrification has increased attention to develop a reliable cryopreservation method to preserve immature equine oocytes.
Mauro Flores Polenz, Gabriel Ribas Pereira, Vitor Braga Rissi, Kalyne Bertolin, Paulo Bayard Gonçalves, Geovani Celso Augusto, Sandra Mara Fiala Rechsteiner   +6 more
doaj   +1 more source