Results 21 to 30 of about 223,551 (298)

Bcl-2-Associated X Protein Is the Main Mediator of Manumycin A-Induced Apoptosis in Anaplastic Thyroid Cancer Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2005
We previously demonstrated that the combination of paclitaxel and manumycin A, a farnesyltransferase inhibitor, enhanced apoptosis of anaplastic thyroid cancer (ATC) cells. However, the mechanism of the manumycin-induced apoptosis is not fully understood.
Jingxuan Pan, Huizhi Huang, Lily Sun, Bingliang Fang, Sai‐Ching J. Yeung   +4 more
openalex   +3 more sources

Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat

Journal of Traditional Chinese Medicine, 2013
To study on effects of Lichong decoction on expression of apoptosis-controlling genes, Bcl-2 and Bcl-2-associated X protein (Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.Fifty Wistar female rats were randomly divided into a normal group, a model group, a Lichong decoction group, a Guizifuling capsule group and a Mifepristone group ...
Donghua Li, Xin Xu, Ruiya Qian, Jianguo Geng, Yan Zhang, Xiaolei Xie, Yasong Wang, Xiaoli Zou   +7 more
openalex   +3 more sources

Preliminary Study On Latent Membrane Protein-1 (LMP-1) And Bcl-2 Associated X (BAX) In Exosomes Of Patients With Nasopharingeal Cancer In NTB Provincial Hospital

KESANS : International Journal of Health and Science, 2021
Nasopharyngeal cancer is one of the most common types of cancer in Indonesia, especially head and neck cancer. One of the etiology of this cancer is infection with Epstein-Barr virus. Early diagnosis is difficult to establish because the early signs and symptoms of nasopharyngeal carcinoma are not specific.
Puput Angrayany Sapar, Hamsu Kadriyan, Didit Yudhanto   +2 more
openalex   +3 more sources

Gene expression profiling ofliver X receptor αandBcl-2-associated X proteinin experimental transection spinal cord-injured rats [PDF]

The Journal of Spinal Cord Medicine, 2013
Study of molecular responses to central nervous system injury would be helpful for controlling the harmful pathways post-injury and triggering the useful pathways required for the treatment of injury.To investigate the expression level of liver X receptor α (LXRα) which has anti-inflammatory effects and pro-apoptotic Bcl-2-associated X protein (Bax ...
Esmat Mohammadi, Kamran Ghaedi, Abolghasem Esmailie, Soheila Rahgozar   +3 more
openalex   +4 more sources

Potential Cytotoxic Activity of Galegine on Human Melanoma Cells [PDF]

Research Journal of Pharmacognosy, 2022
Background and objectives: Melanoma, the most lethal type of skin cancer, has a high recurrence rate within one year in melanoma patients following treatment by chemotherapy or immunotherapy.
Mohammad Hassan Arjmand, Hamed Sabri, Abolfazl Maghrouni, Elmira Zarei, Massoumeh Hotelchi, Amir Reza Afshari*   +5 more
doaj   +1 more source

Establishment of a specific cell death induction system in Bombyx mori by a transgene with the conserved apoptotic regulator, mouse Bcl‐2‐associated X protein (mouse Bax) [PDF]

Insect Molecular Biology, 2015
Abstract The induction of apoptosis in vivo is a useful tool for investigating the functions and importance of particular tissues. B‐cell leukaemia/lymphoma 2‐associated X protein (Bax) functions as a pro‐apoptotic factor and induces apoptosis in several organisms.
Megumi Sumitani, Takeshi Sakurai, Katsumi Kasashima, Shin Kobayashi, Keiro Uchino, Ryohei Kanzaki, Tomohiro Tamura, Hideki Sezutsu   +7 more
openalex   +3 more sources

The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line [PDF]

Middle East Journal of Cancer, 2022
Background: A high number of human breast cancers overexpress the murine double minute (MDM2) gene which blocks the p53 protein which plays an important role in arresting the cell growth.
Tahereh Kalantari, Bahram Mohseni-Aghdam, Fatemeh Nasri, Gholamhossein Tamaddon, Mohsen Kalantari   +4 more
doaj   +1 more source

Effect of Icariin on apoptosis and expression of Fas, Fas ligand, B cell lymphoma, and Bcl-2-associated X protein in CD4 + T lymphocytes from patients with ankylosing spondylitis

Journal of Traditional Chinese Medicine, 2017
To investigate the effects of icariin on apoptosis and the expression of Fas, Fas ligand (FasL), B cell lymphoma (Bcl-2), and Bcl-2-associated X protein (Bax) in CD4＋ T lymphocytes from patients with ankylosing spondylitis.Primary cultures of peripheral blood CD4+ T lymphocytes were established and treated with icariin at high, medium, and low doses (0.
Hailong Wang, Quan Jiang, Xinghua Feng
openalex   +3 more sources

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +21 more sources

Baicalin extracted from Huang qin ( Radix Scutellariae Baicalensis ) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9

Journal of Traditional Chinese Medicine, 2017
To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.
Hongwei Wang, Xiaojun Liu, Chen Feng qin, Luo Jun, Gu Jing, Huping Wang, Hongyan Wu, Xu Guang Yan   +7 more
openalex   +3 more sources