Results 51 to 60 of about 232,551 (308)

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor [PDF]

, 2013
The anti-apoptotic Bcl-2 protein is the founding member and namesake of the Bcl-2-protein family. It has recently been demonstrated that Bcl-2, apart from its anti-apoptotic role at mitochondrial membranes, can also directly interact with the inositol 1 ...
Bultynck, Geert, De Borggraeve, Wim M, De Smedt, Humbert, Decrock, Elke, Leybaert, Luc, Luyten, Tomas, Missiaen, Ludwig, Monaco, Giovanni, Nuyts, Koen, Parys, Jan B, Strelkov, Sergei V, Wagner, Larry E, II, Yule, David I   +12 more
core   +13 more sources

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

Virulence, 2019
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR).
Parvaneh Mehrbod, Sudharsana R. Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K. M. Glover, Affan A. Sher, Kevin M. Coombs, Saeid Ghavami   +10 more
doaj   +1 more source

Alpha-pinene alleviates CCl4-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory ...
Fatemeh Noroozi, Masoumeh Asle Rousta, Rahim Amini, Zeinab Sahraeian   +3 more
doaj   +1 more source

Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways.

Oncology Letters, 2016
Worldwide, colon cancer is the third most common cancer in terms of incidence, following lung and breast cancer. Resistance to psoralidin frequently occurs following its use as an anticancer treatment.
Zhiliang Jin, Wei Yan, Hui Jin, Changzheng Ge, Yanhua Xu   +4 more
semanticscholar   +1 more source

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]

, 2016
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
Anstee, Natasha S., Vandenberg, Cassandra J., Campbell, Kirsteen J., Hughes, Peter D., O’Reilly, Lorraine A., Cory, Suzanne   +5 more
core   +11 more sources

Cytotoxic effects of curcumin on osteosarcoma cell lines [PDF]

, 1969
Summary: Curcumin (diferuloylmethane), one of the main components of the Indian spice turmeric, is known to possess potent anti-inflammatory and anti-oxidant properties.
Walters, Denise, Muff, Roman, Langsam, Bettina, Born, Walter, Fuchs, Bruno   +4 more
core   +1 more source

Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity. [PDF]

, 1998
Bcl-2 has been demonstrated to inhibit apoptosis in breast cancer cells in vitro, and the ratio between Bcl-2 and its proapoptotic homologue Bax seems to be an important determinant of cellular sensitivity to induction of apoptosis.
van de Velde, C. J., van de Vijver, M. J., van Dierendonck, J. H., van Slooten, H. J.   +3 more
core   +3 more sources

Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/endothelial nitric oxide synthase signaling and the B‑cell lymphoma/B‑cell lymphoma‑associated X protein pathway.

Molecular Medicine Reports, 2015
Previous studies have suggested that ginsenoside Rg3 (GSRg3) extract from the medicinal plant Panax ginseng, may increase nitric oxide production via increases in the phosphorylation and expression of endothelial nitric oxide synthase (eNOS). The present
Yiping Wang, Zhaohui Hu, Bing Sun, Jiahong Xu, Jin-fa Jiang, M. Luo   +5 more
semanticscholar   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats

Animals, 2020
Protein nutrition is particularly important for the self-renewal processes of gastrointestinal epithelial cells. The self-renewal of cells is inseparable from the interaction between apoptosis and autophagy.
Zhiwei Kong, Chuanshe Zhou, Jinhe Kang, Zhiliang Tan   +3 more
doaj   +1 more source