Results 51 to 60 of about 223,551 (298)

Targeting BCL-2 regulated apoptosis in cancer [PDF]

, 2018
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J., Tait, Stephen W.J.   +1 more
core   +1 more source

Impact of neurotrophic factors combination therapy on retinitis pigmentosa

Journal of International Medical Research, 2020
Objective We aimed to determine the location of neurotrophic receptors tropomyosin receptor kinase (Trk)B, TrkC, and ciliary neurotrophic factor receptor (CNTFR)α in the retina of retinal degeneration ( rd ) mice and to explore the dynamic changes of B ...
Xiaobei Yin, Ting He, Rui Chen, Hui Cui, Genlin Li   +4 more
doaj   +1 more source

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Bracarda S, Chi KN, Edwards J, Eisenmann KM, Gleave M, Huggins C, Ichinose M, Kelekar A, Lebedeva I, McDonnell TJ   +9 more
core   +1 more source

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

Virulence, 2019
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR).
Parvaneh Mehrbod, Sudharsana R. Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K. M. Glover, Affan A. Sher, Kevin M. Coombs, Saeid Ghavami   +10 more
doaj   +1 more source

Alpha-pinene alleviates CCl4-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory ...
Fatemeh Noroozi, Masoumeh Asle Rousta, Rahim Amini, Zeinab Sahraeian   +3 more
doaj   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Dissecting the pathways of tumour escape: " question of life and death?" Dissecando os caminhos de escape do tumor: "uma questão de vida e morte?"

Anais Brasileiros de Dermatologia, 2010
Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction
Georgi Tchernev, Pietro Nenoff
doaj   +1 more source

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu, Dorn, Gerald W, II, Flavell, Richard A, Han, Qingqing, Hunot, Stephane, Masters, Seth L, Naderer, Thomas, Seidi, Azadeh, Speir, Mary, Vince, James E, Vogrin, Adam   +10 more
core   +4 more sources

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
core   +1 more source