Results 81 to 90 of about 223,423 (198)

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice [PDF]

, 2018
Influenza virus replicates intracellularly exploiting several pathways involved in the regulation of host responses. The outcome and the severity of the infection are thus strongly conditioned by multiple host factors, including age, sex, metabolic ...
Ann Maria Clemente, Anna Rita Vestri, Anna Teresa Palamara, Anna Teresa Palamara, Caterina Loredana Mammola, Danilo Alunni Fegatelli, Donatella Amatore, Enrico Garaci, Ignacio Celestino, Lucia Nencioni, Maria Gabriella Torcia, Marta De Angelis, Paola Checconi, Paola Matarrese, Paolo Coluccio, Romina Mancinelli, Rosanna Dattilo, Walter Malorni   +17 more
core   +2 more sources

Effect of transport stress on apoptosis and autophagy in goat lung cells

Frontiers in Veterinary Science
IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo ...
Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing   +20 more
doaj   +1 more source

Anticancer Effects of Cyclocarya paliurus Polysaccharide (CPP) on Thyroid Carcinoma In Vitro and In Vivo

International Journal of Polymer Science, 2018
In this study, we explored the role and mechanisms of Cyclocarya paliurus polysaccharide on cell apoptosis in thyroid cancer (TC) cells. The apoptosis of thyroid cancer cells in vitro and tumor tissues in vivo induced by Cyclocarya paliurus ...
Zhiwei He, Fangfang Lv, Yueli Gan, Jing Gu, Ting Que   +4 more
doaj   +1 more source

Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

Mediators of Inflammation, 2018
During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling.
Mayumi Iguchi, Miki Hiroi, Haruhide Kanegae, Yoshihiro Ohmori   +3 more
doaj   +1 more source

Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts

, 2023
Joohyun Kang, So-Yeon Kim, Yewon Lee, Jei Oh, Yohan Yoon   +4 more
openalex   +2 more sources

Targeting of the prion protein to the cytosol: mechanisms and consequences

, 2010
Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M., Rambold, A., Tatzelt, J., Winkelhofer, K.   +3 more
core  

Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter [PDF]

, 2002
Although the promoters of both the Bax and p21 genes are activated by p53, they differ in the effect on this activation of the POU family transcription factor Brn-3a. Thus, Brn-3a inhibits activation of the Bax promoter by p53 but enhances the ability of
Budhram-Mahadeo, VS, Latchman, DS, Perez-Sanchez, C   +2 more
core   +2 more sources

Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges

Acta Pharmaceutica Sinica B
For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 mimetics, especially for Bcl-2 inhibitor Venetoclax.
Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao   +5 more
doaj   +1 more source

Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]

, 2017
Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet, Bayir, Hulya, Liu, Bing, Oltvai, Zoltan N, Pak, Stephen C, Perlmutter, David H, Silverman, Gary A   +6 more
core   +3 more sources