Results 91 to 100 of about 36,627,339 (183)

WWOX Induction Promotes Bcl-X_L and Mcl-1 Degradation Through a Lysosomal Pathway upon Stress Responses

Cells
The human WWOX gene resides on a common fragile site and is frequently deleted or altered during DNA replication. WWOX mutations are associated with various human diseases, including cancer, neurodegeneration, and developmental deficits.
Yu-Han Su, Wei Chiang, Yi-Yu Wang, Yi-Hsi Kung, Pai-Shan Cheng, Tsung-Hao Chang, Nan-Shan Chang, Feng-Jie Lai, Li-Jin Hsu   +8 more
doaj   +1 more source

Examination of Bcl-2, Bcl-X and bax protein expression in psoriasis

, 2003
Ozturk Durmaz, Emel/0000-0003-0661-9720Background Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia and greatly accelerated epidermal turnover. The blockage of normal apoptotic process in the epidermis is one of the factors
Bozdogan, O., Erkek, E., Koçak, M., Atasoy, P., Birol, A.   +4 more
core   +1 more source

An investigation into the mechanisms by which bim gene expression is regulated in sympathetic neurons [PDF]

, 2010
Neuronal apoptosis plays a critical role in development and disease. Developing sympathetic neurons require nerve growth factor (NGF) for their survival and die by apoptosis in its absence.
Hughes, R.
core  

Bcl-2 expression and DNA fragmentation in breast carcinoma, pathologic and steroid hormone receptors correlates

, 2012
B-cell leukemia/lymphoma (bcl-2) expression can override the apoptosis development in lymphoid and hormonally regulated tissue-like breast. The presence of estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) have revealed in ...
H J Wolfe (100282), W Carney (100336), Salvador J. Diaz-Cano (100072), M Garcia-Moliner (100335)   +3 more
core   +1 more source

Mitochondrial proteins (e.g. VDAC, Bcl-2, HK, ANT...) as major control points in oncology

Frontiers in Oncology, 2014
Catherine eBrenner, antoinette eLemoine
doaj   +1 more source

A novel recombinant expression and purification approach for the full-length anti-apoptotic membrane protein Bcl-2

, 2020
Programmed cell death (apoptosis) is an essential mechanism in life that tightly regulates embryogenesis and removal of harmful cells. Besides an extrinsic pathway, an intrinsic (mitochondrial) apoptotic pathway exists where mitochondria are actively ...
Ul Mushtaq, Ameeq,, Dingeldein, Artur P. G.,, Gröbner, Gerhard,, Wallgren, Marcus,, Ådén, Jörgen,   +4 more
core   +1 more source

The association of sperm BAX and BCL-2 gene expression with reproductive outcome in Oligoasthenoteratozoospermia cases undergoing intracytoplasmic sperm injection: A case-control study

International Journal of Reproductive BioMedicine
Background: The B-cell lymphoma 2 (BCL-2) protein is one of the members of the BCL-2 associated X (BAX) protein family that acts as an inducer of apoptosis.
Fatemeh Babaei, Maryam Khoshsokhan Muzaffar, Rahil Jannatifar   +2 more
doaj   +1 more source

The role of the adipokine chemerin in prostate cancer [PDF]

Obesity is a major health problem worldwide and its effects on the cardiovascular system are well documented. It also leads to the development of metabolic disease such as insulin resistance and diabetes.
Williams, Kevin George
core  

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

, 2019
BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK a multidomain BCL-2 family protein is generally believed to be an adaptor protein similar to BAK and BAX regulating the mitochondrial permeability transition during apoptosis.
Fiona Brown (1432693), Daniel Bachmann (10216680), Rob Ramsay (12998322), Jason Glab (9475100), Thomas Kaufmann (509918), Francine Ke (12998310), Lorraine O'Reilly (12998313), Andrew Kueh (20405420), Lahiru Gangoda (9498728), Tatiana Rabachini (177169), Suresh Mathivanan (9487679), Andrew Wei (410691), Zhipeng Cao (9491657), Joseph Menassa (9482459), Brian Smith (9487481), Sanjay Shahi (9479723), Cody Allison (12998316), Yuniel Fernandez-Marrero (12998307), Hamsa Puthalakath (9481346), Christina Nedeva (11406338), Samara Naim (12998304), Tao Nelson (9475148), Rahul Srivastava (9474350), Marcel Doerflinger (10829874), Laura Murray-Rust (9478424)   +24 more
core   +1 more source

Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway

Frontiers in Pharmacology
BackgroundThis study aimed to investigate the molecular mechanism by which the Harmine derivative B-9-3 inhibits angiogenesis and promotes apoptosis in non-small cell lung cancer (NSCLC).MethodsThree non-small cell lung cancer (NSCLC) models (human NSCLC
Yuche Wu, Yuche Wu, Bing Wang, Xuwen Mao, Wei Chen, Haji Akber Aisa   +5 more
doaj   +1 more source