Results 91 to 100 of about 213,161 (287)

Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-xL [PDF]

, 2000
Bcl-x(l) and Bax play important roles in the regulation of apoptosis. This study investigated the involvement of the mitochondrial death pathway and the role of Bcl-x(l) and Bax in the escape from apoptosis after prolonged serum deprivation in Madin ...
Endre, Z, Zhang, Xiao-Ju, Cuttle, Leila, Endre, Zoltan, Cuttle, L., Zhang, XJ, Zhang, X., Yan, J., Endre, Z. H., Cuttle, L, Yan, J, Gobe, Glenda, Yan, Jun, Gobe, G. C., Gobe, G   +14 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Eventos apoptóticos induzidos pelo Lauril Galato sobre células de leucemia mielóide aguda humana K562 [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasThe purpose of the present study was to investigate the sensibility of human myeloid leukemia cells (K562) to the ...
Ferreira, Samira Cardoso
core  

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. [PDF]

, 2011
A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the BH3 α-helical domain of pro-apoptotic proteins such as Bax, Bak ...
Jiazhi Sun, Yoshinori Takahashi, Saïd M. Sebti, Sebti, SM, Johanna M. Rodriguez, Yin, H, Hamilton, Andrew, Hong-Gang Wang, Shen-Shu Sung, Andrew D. Hamilton, Sung, SS, Hamilton, AD, Wang, HG, Aslamuzzaman Kazi, Berndt, N, Kazi, A, Rodriguez, JM, Becerril, J, Norbert Berndt, Sun, J, Doi, K, Hang Yin, Jorge Becerril, Kenichiro Doi, Takahashi, Y   +24 more
core   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

Frontiers in Cellular Neuroscience
Intracerebral hemorrhage (ICH) is a severe condition that devastatingly harms human health and poses a financial burden on families and society. Bcl-2 Associated X-protein (Bax) and B-cell lymphoma 2 (Bcl-2) are two classic apoptotic markers post-ICH ...
Moyan Wang, Xin Chen, Shuangyang Li, Lingxue Wang, Hongmei Tang, Yuting Pu, Dechou Zhang, Dechou Zhang, Bangjiang Fang, Bangjiang Fang, Xue Bai, Xue Bai   +11 more
doaj   +1 more source

Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats.

PLoS ONE, 2018
BACKGROUND:The purpose of this study was to investigate the combined 17β-estradiol (E2) and exercise training on cardiac pro-survival and anti-apoptotic pathways in ovariectomized rats.
Yi-Yuan Lin, Jwo-Sheng Chen, Xu-Bo Wu, Woei-Cherng Shyu, Rungchai Chaunchaiyakul, Xian-Li Zhao, Chia-Hua Kuo, Yu-Jung Cheng, Ai-Lun Yang, Shin-Da Lee   +9 more
doaj   +1 more source

1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells

Molecules, 2019
1-O-Hexyl-2,3,5-trimethylhydroquinone (HTHQ) has previously been found to have effective anti-oxidant and anti-lipid-peroxidative activity. We aimed to elucidate whether HTHQ can prevent dopaminergic neuronal cell death by investigating the effect on l ...
Hyun Jin Park, Jong Koo Kang, Myung Koo Lee   +2 more
doaj   +1 more source

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy? [PDF]

, 2018
Bibi Kulsoom,1 Tahir Sultan Shamsi,1 Nasir Ali Afsar,2,3 Zahida Memon,4 Nikhat Ahmed,4 Syed Nazrul Hasnain5 1National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Jinnah Medical and Dental College, Karachi, Pakistan ...
Shamsi TS, Memon Z, Hasnain SN, Afsar NA, Kulsoom B, Ahmed N   +5 more
core  

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source