Results 81 to 90 of about 213,161 (287)

Proteasome Inhibitor MG132 is Toxic and Inhibits the Proliferation of Rat Neural Stem Cells but Increases BDNF Expression to Protect Neurons

Biomolecules, 2020
Regulation of protein expression is essential for maintaining normal cell function. Proteasomes play important roles in protein degradation and dysregulation of proteasomes is implicated in neurodegenerative disorders.
Young Min Kim, Hyun-Jung Kim
doaj   +1 more source

Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3

Open Medicine, 2023
Considering the role of glycolysis inhibition as a novel therapeutic strategy for cancer, including breast cancer (BC), we wondered whether glycolysis could affect BC progression by regulating transmembrane O-mannosyltransferase-targeting cadherins 3 ...
Hu Xue, Guo Baoliang, Sun Tong, Wang Wan
doaj   +1 more source

Regulation of Mitochondria-dependent Apoptosis in Non-Small Cell Lung Cancer: Implications for Cancer Therapy [PDF]

, 2007
Summary The work described in this thesis focuses on the characterization of the mechanism(s) underlying the deregulated activation of the intrinsic or mitochondrial apoptotic pathway in non-small cell lung cancer (NSCLC) cells.
Checinska, A.
core   +1 more source

Unidirectional crosstalk between Bcl-x(L) and Bcl-2 enhances the angiogenic phenotype of endothelial cells [PDF]

, 2007
Expression of Bcl-x(L) correlates with the clinical outcomes of patients with cancer. While the role of Bcl-2 in angiogenesis is becoming increasingly evident, the function of Bcl-x(L) in angiogenesis is unclear.
Nunez, G, Koch, AE, Neiva, KG, M S Soengas, Dong, Z, K G Neiva, Zhang, Z, Polverini, PJ, E Karl, Karl, E, G Núñez, Z Zhang, Nor, Jacques, A E Koch, Z Dong, J E Nör, Soengas, MS, P J Polverini   +17 more
core   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak [PDF]

, 2015
The apoptotic behavior of ameloblastomas was studied using antibodies against the apoptosis related proteins, Bcl-2, Bcl-X, Bax and Bak. Most of the outer layer cells were predominantly stained by the antimodulating proteins, Bax and Bak. Among the Bcl-2
Ferry Sandra, Masamichi Ohishi, Hiroshi Takeuchi, Norifumi Naksmura, Takeshi Misuyasu, Yuji Shiratsuchi   +5 more
core   +4 more sources

Scrophularia buergeriana Extract Improves Memory Impairment via Inhibition of the Apoptosis Pathway in the Mouse Hippocampus

Applied Sciences, 2020
Scrophularia buergeriana (SB) Miq. (Scrophulariaceae) has been used to help cure swelling and fever and has reported antioxidant and neuro-protective effects.
Hae Jin Lee, Dae Young Lee, Hae Lim Kim, Seung Hwan Yang   +3 more
doaj   +1 more source

Bcl-X-L translocation in renal tubular epithelial cells in vitro protects distal cells from oxidative stress [PDF]

, 2001
Background. The molecular pathogenesis of different sensitivities of the renal proximal and distal tubular cell populations to ischemic injury, including ischemia-reperfusion (IR)-induced oxidative stress, is not well-defined.
Zhang, Xiao-Ju, Zhang, X. J., Cuttle, Leila, Winterford, Clay, Gobé, Glenda C., Cuttle, L., Endre, Z. H., Winterford, C., Gobe, G. C., Endre, Zoltan H.   +9 more
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Protective Effect of Nervonic Acid on Oxidative Damage of PC12 Cells Induced by H2O2 [PDF]

Shipin Kexue
This study developed a cell model of oxidative damage by treating PC12 cells for 24 h with 200 µmol/L H2O2 and determined the degree of oxidative stress by assaying the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and lactate
Mayile AIHAITI, LIU Yaojie, LI Jianke
doaj   +1 more source