Results 81 to 90 of about 36,627,339 (183)

Effect of transport stress on apoptosis and autophagy in goat lung cells

Frontiers in Veterinary Science
IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo ...
Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing   +20 more
doaj   +1 more source

Anticancer Effects of Cyclocarya paliurus Polysaccharide (CPP) on Thyroid Carcinoma In Vitro and In Vivo

International Journal of Polymer Science, 2018
In this study, we explored the role and mechanisms of Cyclocarya paliurus polysaccharide on cell apoptosis in thyroid cancer (TC) cells. The apoptosis of thyroid cancer cells in vitro and tumor tissues in vivo induced by Cyclocarya paliurus ...
Zhiwei He, Fangfang Lv, Yueli Gan, Jing Gu, Ting Que   +4 more
doaj   +1 more source

Heterogeneity of viral IL-6 expression in HHV-8-associated diseases. [PDF]

, 2007
In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens.
Cesarman, Ethel, Nicholas, John, Cannon, Jennifer S., Murray, Paul G., Ambinder, Richard F., Orenstein, Jan M., Mann, Risa B., DiGiuseppe, Joseph A., Hayward, Gary S., Browning, Philip J.   +9 more
core   +1 more source

Process for preparing exosome loading Bcl-2-associated X protein, and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient

, 2018
본 발명은 Bax(Bcl-2-associated X protein) 단백질을 포함하는 엑소솜(Bax:EXPLOR)을 대량으로 제조하는 방법, 상기 엑소솜 제조에 사용될 수 있는 엑소솜 제조용 벡터, 상기 방법으로 제조된 Bax(Bcl-2-associated X protein) 단백질을 포함하는 엑소솜 및 이를 유효성분으로 함유하는 항암용 약학적 조성물에 관한 것이다.
류승욱, 최철희, 최경선, 임남빈   +3 more
core   +1 more source

Suppression of Transcription Factor Nfκb Activity by Bcl-2 Protein in Nih 3t3 Cells: Implication of a Novel Nfκbp50-Bcl-2 Complex for the Anti- Apoptotic Function of Bcl-2

, 2009
Bcl-2 can suppress apoptosis by controlling genes that encode proteins required for programmed cell death and by interference with peroxidative damage.
侯自銓;林仁混, HOUR, TZYH-CHYUAN;CHEN, LINDA;LIN, JEN-KUN   +1 more
core  

Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges

Acta Pharmaceutica Sinica B
For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 mimetics, especially for Bcl-2 inhibitor Venetoclax.
Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao   +5 more
doaj   +1 more source

Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

Mediators of Inflammation, 2018
During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling.
Mayumi Iguchi, Miki Hiroi, Haruhide Kanegae, Yoshihiro Ohmori   +3 more
doaj   +1 more source

Eventos apoptóticos induzidos pelo Lauril Galato sobre células de leucemia mielóide aguda humana K562 [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasThe purpose of the present study was to investigate the sensibility of human myeloid leukemia cells (K562) to the ...
Ferreira, Samira Cardoso
core  

Expression and purification of full-length anti-apoptotic Bcl-2 using cell-free protein synthesis

, 2011
The anti-apoptotic B cell CLL/lymphoma-2 (Bcl-2) protein is a key player in the regulation of programmed cell death and is linked to various types of cancer and their resistance to drug treatment.
Pedersen, Anders,, Gerhard Gröbner, Gröbner, Gerhard,, Anders Pedersen, Wallgren, Marcus,, Wallgren, Marcus, Marcus Wallgren, B. Göran Karlsson, Karlsson, B Göran,, Gröbner, Gerhard   +9 more
core   +1 more source

Expression of Drug Targets in Patients Treated with Sorafenib, Carboplatin and Paclitaxel [PDF]

, 2013
Introduction: Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases.
John M Kirkwood, Keith T Flaherty, Fengmin Zhao (139710), Kluger Harriet M., Wilson, M, Harriet M Kluger, Jilaveanu Lucia B., Rimm, DL, Lee, Sandra J., Kurt D'Andrea (442217), Rimm David L., Harriet M. Kluger (184091), Kluger, HM, D'Andrea, Kurt, Zhao, F, Kurt D'Andrea, Melissa Wilson (442218), Keith T. Flaherty (226339), Nathanson, KL, Kirkwood, John M., Sandra J. Lee (213144), Lee Sandra J., Fengmin Zhao, D'Andrea, K, Zhao, Fengmin, David L. Rimm (323315), Kirkwood, JM, Flaherty Keith T., Kirkwood John M., Sandra J Lee, Wilson Melissa, Katherine L Nathanson, Flaherty, Keith T., Jilaveanu, LB, John M. Kirkwood (141762), David L Rimm, Rimm, David L., Nathanson Katherine L., Zito, Christopher R., D'Andrea Kurt, Zito, CR, Lucia B Jilaveanu, Zhao Fengmin, Wilson, Melissa, Jilaveanu, Lucia B., Flaherty, KT, Lee, SJ, Katherine L. Nathanson (154077), Melissa Wilson, Smalley, Keiran, Lucia B. Jilaveanu (184077), Kluger, Harriet M., Christopher R. Zito (184074), Zito Christopher R., Christopher R Zito, Nathanson, Katherine L.   +55 more
core   +2 more sources