Results 141 to 150 of about 231,834 (240)

Reprogramming the Apoptosis-Autophagy Axis in Glioblastoma: The Central Role of the Bcl-2:Beclin-1 Complex and Survival Signalling Networks. [PDF]

Cells
Christoff M, Szczepańska A, Jakubowicz-Gil J, Zając A.   +3 more
europepmc   +1 more source

Fibroblast Plasticity in Inflammation of the Barrier

Barrier Immunity, EarlyView.
Under inflammatory condition, fibroblasts in barrier tissues integrate inflammatory, senescent, and mechanical inputs. These pathways activate central signaling networks to drive fibroblast phenotypic transition, enabling cytokine production, immune cell recruitment, and extracellular matrix remodeling.
Chen Zhang, Hao Wu, Wei Li
wiley   +1 more source

BCL-2 Family Inhibition Enhances mTORC1/2 Inhibition in PIK3CA-Mutant Colorectal Cancer. [PDF]

Mol Cancer Ther
DeStefanis RA, Schmitz AE, Steimle AK, Payne SN, Sha GC, Olson AM, Cornelio A, Lippert AEL, Kraus SG, Johnson KA, Favreau PF, Gillette A, Babiarz C, Miller D, Sprackling CM, Pasch CA, Pritzl S, Van De Hey DR, Korkos DP, Foley TM, Yueh AE, Greane ALJX, Clipson L, Skala MC, Deming DA.   +24 more
europepmc   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Hydroxysafflor yellow A attenuates sepsis-induced intestinal barrier dysfunction by modulating Bcl-2/SOD2-mediated mitochondrial apoptosis. [PDF]

Front Pharmacol
Fei J, Xu C, Chen C, Chen Q, Wu Z, Wang Y, Bao D, Shao S.   +7 more
europepmc   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Bcl-2 and FAS as Apoptosis-Related Markers in Patients with Convulsive Status Epilepticus. [PDF]

J Clin Med
Ćorić L, Sović S, Šimac B, Mihaljević I, Vukasović I, Čolak Romić Z, Šušak Sporiš I, Petelin Gadže Ž.   +7 more
europepmc   +1 more source

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis. [PDF]

J Exp Clin Cancer Res
Soni S, Anang V, Zhao Y, Horowitz JC, Nho RS, Mebratu YA.   +5 more
europepmc   +1 more source