Results 161 to 170 of about 369,993 (297)

PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer

Cells
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in ...
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou   +7 more
doaj   +1 more source

Detection of bcl-2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis

, 1993
Renbing� Yuan, P Dowling, Emanuele Zucca, Heidi Diggelmann, Franco Cavalli   +4 more
openalex   +2 more sources

bcl‐2 Regulation in Normal Resting Lymphocytes and Lymphoblasts [PDF]

, 1994
Eisaku Kendo, Tadashi Yoshino, Shintaro Nomura, Shuji Nakamura, Kiyoshi Takahashi, Norihiro Teramoto, Kazuhiko Hayashi, Tadaatsu Akagi   +7 more
openalex   +1 more source

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature Communications
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and ...
Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen   +12 more
doaj   +1 more source

Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma

, 1994
Gabriel
openalex   +2 more sources

Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes [PDF]

, 1994
T. Yoshino, E Kondo, Ling Cao, Ken Takahashi, K Hayashi, S Nomura, T Akagi   +6 more
openalex   +1 more source

Bcl-2 dependent modulation of Hippo pathway in cancer cells

Cell Communication and Signaling
Introduction Bcl-2 and Bcl-xL are the most studied anti-apoptotic members of Bcl-2 family proteins. We previously characterized both of them, not only for their role in regulating apoptosis and resistance to therapy in cancer cells, but also for their ...
Simona D’Aguanno, Matteo Brignone, Stefano Scalera, Martina Chiacchiarini, Marta Di Martile, Elisabetta Valentini, Francesca De Nicola, Alessia Ricci, Fabio Pelle, Claudio Botti, Marcello Maugeri-Saccà, Donatella Del Bufalo   +11 more
doaj   +1 more source

The bcl-2 oncogene in Hodgkin's disease arising in the setting of follicular non-Hodgkin's lymphoma [PDF]

, 1994
DP LeBrun, BY Ngan, Weiss Lm, Phil Huie, RA Warnke, ML Cleary   +5 more
openalex   +1 more source

bcl-2 Protein in Non-Small-Cell Lung Carcinoma [PDF]

, 1993
Francesco Pezzella, Helen Turley, Işınsu Kuzu, M F Tungekar, M. S. Dunnill, Chris Pierce, Adrian L. Harris, Kevin C. Gatter, David Y. Mason   +8 more
openalex   +1 more source

Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits

Animal Research and One Health, EarlyView.
Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni, Zhitong Wang, Zhichao Li, Mengjuan Chen, Hui He, Hanfang Cai, Zhi Chen, Ming Li, Huifen Xu   +8 more
wiley   +1 more source