Results 201 to 210 of about 17,898,482 (301)

Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in <i>TP53-</i>mutated acute myeloid leukemia. [PDF]

Front Cell Dev Biol
Iqbal U, Shallis RM.
europepmc   +1 more source

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source

Platycodin D alleviates cardiac hypertrophy in the treatment of heart failure by inhibiting p53-dependent BCL-2/Bax/caspase-3 signaling pathway. [PDF]

Front Pharmacol
Li Y, Li H, Liu B, Li Y.
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

In vitro bioactivity, cytotoxicity, and gene silencing of graphene oxide as a Bcl-2 siRNA carrier in osteosarcoma cells with in vivo inflammatory response. [PDF]

Sci Rep
Saravanabhavan SS, Sarang Z, Marimuthu N, Raju SVV, Nissapatorn V, Sergi CM.   +5 more
europepmc   +1 more source

BCL-2 Inhibitor [PDF]

, 2020
openaire   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Evaluation of mTOR, NFκB, and BCL-2 Inhibitor Activity In Vitro on Diffuse Large B-Cell Lymphoma Cells. [PDF]

Curr Issues Mol Biol
Majchrzak A, Mańka S, Cebula-Obrzut B, Mędra A, Robak P, Mikulski D, Witkowska M.   +6 more
europepmc   +1 more source

Diagnostic Performance of Baseline FDG‐PET/CT for Detecting Bone Marrow Involvement in Classic Follicular Lymphoma

iRADIOLOGY, EarlyView.
For patients with diffuse component, the presence of bulky disease and spleen involvement is strongly predictive of BMB‐confirmed BMI. Conversely, the absence of PET/CT‐detected BMI, bulky disease, and splenic involvement suggests a low likelihood of BMB‐confirmed BMI.
Haoying Huang, Yingying Zhang, Jiajia Dong, Yeye Zhou, Jihui Li, Xin Xu, Na Dai, Bin Zhang   +7 more
wiley   +1 more source

Cassipourol and β-sitosterol from Malva parviflora L.: a mechanistic study of dual anti-inflammatory action against COX/LOX and TNF-α/BCL-2. [PDF]

Sci Rep
Anwar MA, El Gedaily RA, Aboulthana WM, Elshewy A, Kandil ZA, Abdel-Dayem SIA.   +5 more
europepmc   +1 more source