Results 211 to 220 of about 24,683,651 (289)

Differential Modulation of JAK/STAT3 Signaling and BCL-2 Family Proteins by Tetracycline Analogues in Leukemia Models. [PDF]

Pharmaceutics
Hassan ZM, Mamand DR, El-Gawly HW, El-Sherbeeny NA, Mohammad HMF, Mohammad HMF, Elkherbetawy MK, Wiklander OPB, Hassan M.   +8 more
europepmc   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Statement of Retraction: SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. [PDF]

Bioengineered
europepmc   +1 more source

Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors. [PDF]

Drug Dev Res
Chan AM, Eberly C, Drennen B, Goodis CC, Wuyts Z, Civin CI, Fletcher S.   +6 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2-targeted therapy. [PDF]

Front Med (Lausanne)
He M, Zhou Y, Yao J, Zhang Q, Xu W, Ye X, Cai Y, Liu Z.   +7 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Dynamical analysis of a model of BCL-2-dependent cellular decision making. [PDF]

NPJ Syst Biol Appl
Cloete I, Alarcón T.
europepmc   +1 more source

Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure

Chemistry – A European Journal, EarlyView.
The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio, Marko Trajkovski, Janez Plavec, Claudia Sissi   +3 more
wiley   +1 more source

H₂S induces apoptosis of tumors with high IDO1 expression via NR4A1-BCL-2 and SOCS3 pathways. [PDF]

Cell Mol Biol Lett
He ZNT, Meng F, Qian X, Liu Y, Fang X, Yang D, Yang Q.   +6 more
europepmc   +1 more source