Results 231 to 240 of about 377,868 (302)

Metachronous Presentation of BCL-2-Positive Lung Adenocarcinoma and Acute Myeloid Leukemia: A Case Presentation and Review of the Literature. [PDF]

Case Rep Oncol
Zhang Y, Zheng B, Yi K, Pang T, Zhu L, Zhou J, Xu C, He J, Xu C, Chen J, Yu M, Chen M, Chen C, Lan H, Li R.   +14 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

[Retracted] MicroRNA-24-3p inhibition prevents cell growth of vascular smooth muscle cells by targeting Bcl-2-like protein 11. [PDF]

Exp Ther Med
Zhang H, Xue S, Feng Y, Shen J, Zhao J.
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Mechano-matching hydrogel patch promotes myocardial infarction repair via YAP-Bcl-2 pathway activation. [PDF]

Mater Today Bio
Zhao Y, Shen J, Lin R, Huang J, Zou X, Hou H, Qiu X.   +6 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Bcl-2 inhibitor resistance in diffuse large b-cell lymphoma: establishing a prognostic signature and targeting alpha protein kinase 1. [PDF]

Front Oncol
Ma J, Wang Y, Liu H, Deng Y, Shi Y, Wei L, Chen Q, Wang C, Yu L.   +8 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity. [PDF]

Cell Death Dis
Newman DM, Andersen CL, Cluse LA, Newbold A, Fraser P, Legg BWC, Xu LK, Mele DA, Johnstone RW.   +8 more
europepmc   +1 more source

The Impact of Dance Interventions on Adolescents’ Prosocial Behavior: A Scoping Review

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescents are increasingly affected by complex societal challenges that impact their psychosocial development. Prosocial behaviors such as empathy, cooperation, and peer support are critical during this stage and contribute to positive academic, emotional, and social outcomes.
Chloe L. Brown, Carolynne L. J. Mason, Jennie E. Hancox, Colin J. Deal, Min Du   +4 more
wiley   +1 more source