Results 271 to 280 of about 369,993 (297)

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Dual targeting of HSP90 and BCL-2 in breast cancer cells using inhibitors BIIB021 and ABT-263. [PDF]

Breast Cancer Res Treat
Gökşen Tosun N, Kaplan Ö.
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia. [PDF]

Cancer Biol Ther
Li J, Ye C, Li H, Li J.
europepmc   +1 more source

Apoptosis regulators of the Bcl‐2 family play a key role in chemoresistance of cholangiocarcinoma organoids

International Journal of Cancer, EarlyView.
What's New? Poor prognosis in cholangiocarcinoma (CCA) is attributed to late diagnosis and intrinsic chemoresistance. In particular, resistance mechanisms that suppress apoptosis limit the effectiveness of gemcitabine‐based regimens, which remain the standard treatment.
Wunan Mi, Gilles S. van Tienderen, Shaojun Shi, Amy Broeders, Kathryn Monfils, Henk P. Roest, Luc J. W. van der Laan, Monique M. A. Verstegen   +7 more
wiley   +1 more source

Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts. [PDF]

Front Pharmacol
Lin Y, Zhao R, Huang J, Chen T, Yang H, Guo H, Wan L, Zhang Z, Li Y, Zhu G, Huang H.   +10 more
europepmc   +1 more source

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source

Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy. [PDF]

Biomol Ther (Seoul)
Dakkak BE, Taneera J, El-Huneidi W, Abu-Gharbieh E, Hamoudi R, Semreen MH, Soares NC, Abu-Rish EY, Alkawareek MY, Alkilany AM, Bustanji Y.   +10 more
europepmc   +1 more source

Underlying Mechanism of Jiuwei Shengmai Powder in Improving Myocardial Hypoxia at High Altitude Based on Network Pharmacology and Molecular Docking

iLABMED, EarlyView.
The expression pathway of COX and the downstream mechanism of PGE. M: muscarinic receptor; PL: phospholipid; PLA2: phospholipase A2; AA: arachidonic acid; EP1: prostaglandin E1 receptor; EP2: prostaglandin E2 receptor; EP3: prostaglandin E3 receptor; EP4: prostaglandin E4 receptor.
Cong Wu, Yanjuan Zhu, Changpeng Xie, Haobo Liu, Yuanming Pan, Chang'e Liu   +5 more
wiley   +1 more source

Calaspargase-Pegol-Mknl Combined with BCL-2 and MCL-1 Inhibition for Acute Myeloid Leukemia. [PDF]

Int J Mol Sci
Bollino D, Ma X, Tighe KM, Casildo A, Richard K, Passaniti A, Carter-Cooper B, Strovel ET, Emadi A.   +8 more
europepmc   +1 more source