Results 261 to 270 of about 377,868 (302)
Some of the next articles are maybe not open access.
1999
Apoptosis is an increasingly well described, but still poorly understood, mechanism for killing metazoan cells (Kerr et al. 1972; Wyllie et al. 1980). It is fundamental to processes as diverse as tissue remodelling during embryogenesis, maintenance of tissue homeostasis in the adult and to both innate and cognate immunity (Ellis et al.
L, O'Connor, A, Strasser
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Apoptosis is an increasingly well described, but still poorly understood, mechanism for killing metazoan cells (Kerr et al. 1972; Wyllie et al. 1980). It is fundamental to processes as diverse as tissue remodelling during embryogenesis, maintenance of tissue homeostasis in the adult and to both innate and cognate immunity (Ellis et al.
L, O'Connor, A, Strasser
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Role of Caspase 3-Dependent Bcl-2 Cleavage in Potentiation of Apoptosis by Bcl-2
Molecular Pharmacology, 2002Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells. In the present study, we examine the mechanisms of this effect and demonstrate its relevance for the in vivo situation. Four hours after NCS treatment, a 23-kDa cleavage product of Bcl-2 was detected
Ye, Liang +3 more
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Expression of Bcl-2 Protein and Bcl-2 mRNA in Normal and Neoplastic Lymphoid Tissues
Leukemia & Lymphoma, 1994The bcl-2 gene is a unique proto-oncogene that blocks apoptosis; its product is localized on the inner mitochondrial membrane. In non neoplastic human lymphoid tissues, bcl-2 protein is strongly expressed in the small recirculating lymphocytes of the follicular mantle zone; it is expressed less intensely in T-cell areas, and is almost absent from ...
T, Akagi, E, Kondo, T, Yoshino
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2004
A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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2000
Abstract Human bcl-2 gene was isolated from the analysis of t(14;l8) (q32;q21) chromosomal translocation frequently found in follicular lymphoma (1). Overexpression of Bcl-2 prevents apoptosis induced by a variety of stimuli in various cell lineage (2).
Yutaka Eguclll, Yoshij-Iidf Tsujimoto
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Abstract Human bcl-2 gene was isolated from the analysis of t(14;l8) (q32;q21) chromosomal translocation frequently found in follicular lymphoma (1). Overexpression of Bcl-2 prevents apoptosis induced by a variety of stimuli in various cell lineage (2).
Yutaka Eguclll, Yoshij-Iidf Tsujimoto
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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Nature Reviews Drug Discovery, 2017Avi Ashkenazi, Wayne J Fairbrother
exaly