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Role of Caspase 3-Dependent Bcl-2 Cleavage in Potentiation of Apoptosis by Bcl-2
Molecular Pharmacology, 2002Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells. In the present study, we examine the mechanisms of this effect and demonstrate its relevance for the in vivo situation. Four hours after NCS treatment, a 23-kDa cleavage product of Bcl-2 was detected
Ye, Liang +3 more
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Expression of Bcl-2 Protein and Bcl-2 mRNA in Normal and Neoplastic Lymphoid Tissues
Leukemia & Lymphoma, 1994The bcl-2 gene is a unique proto-oncogene that blocks apoptosis; its product is localized on the inner mitochondrial membrane. In non neoplastic human lymphoid tissues, bcl-2 protein is strongly expressed in the small recirculating lymphocytes of the follicular mantle zone; it is expressed less intensely in T-cell areas, and is almost absent from ...
T, Akagi, E, Kondo, T, Yoshino
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2004
A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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2000
Abstract Human bcl-2 gene was isolated from the analysis of t(14;l8) (q32;q21) chromosomal translocation frequently found in follicular lymphoma (1). Overexpression of Bcl-2 prevents apoptosis induced by a variety of stimuli in various cell lineage (2).
Yutaka Eguclll, Yoshij-Iidf Tsujimoto
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Abstract Human bcl-2 gene was isolated from the analysis of t(14;l8) (q32;q21) chromosomal translocation frequently found in follicular lymphoma (1). Overexpression of Bcl-2 prevents apoptosis induced by a variety of stimuli in various cell lineage (2).
Yutaka Eguclll, Yoshij-Iidf Tsujimoto
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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Nature Reviews Drug Discovery, 2017Avi Ashkenazi +2 more
exaly