Results 141 to 150 of about 134,892 (289)

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

European Journal of Organic Chemistry, EarlyView.
Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Expression of p53 and bcl2 in squamous cell carcinoma of head and neck

Archives of Clinical and Experimental Surgery, 2016
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth-most common malignancy worldwide. Despite advances in radiotherapy and surgical treatment, survival rates have not changed significantly in the last 40 years.
Kanika Taneja, Sumiti Gupta, Ashok Chauhan, Rajnish Kalra, Aditi Arora, Sohrab Arora, Rajeev Sen   +6 more
doaj   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Exploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong, Xin Han, Qiao Yang, Roufen Chen, Liteng Shen, Lei Xu, Lu Wang, Bo Zhu, Dongxin Tang, Shuosheng Zhang, Keda Lu, Mengyun Peng, Gang Cao   +15 more
wiley   +1 more source

Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of \u3ci\u3eBIM\u3c/i\u3e mRNA with small interfering RNA and short hairpin RNA. [PDF]

, 2004
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the treatment of leukemia. The activated glucocorticoid receptor (GR) initiates a transcriptional program leading to caspase activation and cell death, but the critical ...
Abrams, Marc T., Robertson, Noreen M., Wickstrom, Eric, Yoon, Kyonggeun   +3 more
core   +1 more source

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers

Ibrain, EarlyView.
This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino, Annalisa Bianco, Valeria De Matteis, Edoardo Scarpa, Rosaria Rinaldi   +4 more
wiley   +1 more source

Effect of Petiveria alliacea leaf extract and its active components on heart muscle cell apoptosis induced by hyperglycemia

Open Veterinary Journal
Background: Hyperglycemia is a condition in which blood sugar levels increase excessively due to a variety of factors, one of which is the body's inability to regulate insulin properly.
Nurmawati Fatimah, Sri Agus Sudjarwo, Arifa Mustika, Suharjono Suharjono, Jusak Nugraha, Hari Basuki Notobroto, Rochmah Kurnijasanti, Reny I'tishom, Wibi Riawan, Alphania Rahniayu   +9 more
doaj   +1 more source

The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. [PDF]

, 2015
The orphan Gα13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R   +2 more
core  

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source