Results 131 to 140 of about 108,551 (297)

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Bcl2 mRNA stability and protein expression are diminished in the absence of the Bcl2 ARE-rich sequence.

, 2015
A, qPCR analysis of Bcl2 mRNA levels in LN B cells from C57BL/6 (wt/wt), Bcl2-AREflox/flox x mb1wt (flox/flox) and Bcl2-AREflox/flox x mb1cre (∆/∆) mice. B, Relative quantification of Bcl2 mRNA in splenic B cells before and after stimulation with LPS (10
Manuel D. Díaz-Muñoz (697559), Martin Turner (391990), Sarah E. Bell (697560)   +2 more
core   +1 more source

Evaluation of Lactobacillus Sakei Probiotic Supernatant’s Effectiveness in Promoting Apoptosis and Decreasing Breast Cancer MCF-7 Cancerous Cells through Modulation of Bax and Bcl2 Genes [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Accumulating evidence has revealed that inducing apoptosis is an important strategy to control excessive breast cancer cell proliferation.
Elham Hemati, Hossein Sazegar
doaj  

Menin and BCL2 inhibitors– shaken and stirred

Haematologica
Not available.
Alex, Bataller, Ghayas C, Issa
openaire   +2 more sources

BCL2 and JUNB abnormalities in primary cutaneous lymphomas

, 2004
Background BCL2 is upregulated in nodal and extranodal B-cell non-Hodgkin's lymphomas, with a consequent antiapoptotic effect. However, loss of BCL2 has also been noted in some malignancies, suggesting a different molecular pathogenesis.
Young, B D, Orchard, G, Child, F J, Vonderheid, E C, Bagot, M, Bensussan, A, Nowell, P C, Russell-Jones, R, Mao, X, Lillington, D M, Whittaker, S J   +10 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Comparison of the effects of pure vitamin E and combined conservative therapy for precancerous cervical lesions cultivated on a microfluidic chip

Open Medicine
We aimed to examine the effect of vitamin E on preinvasive cervical squamous epithelium lesions on a microfluidic chip model.
Perić Anđela, Mirić Ana N., Košarić Jelena V., Milivojević Nevena N., Živanović Marko N., Milosavljević Miloš N., Protrka Simona, Arsenijević Petar S.   +7 more
doaj   +1 more source

AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

Summary: The accumulation of damaged mitochondria in the heart is associated with heart failure. Mitophagy is an autophagic degradation system that specifically targets damaged mitochondria.
Min Zhang, Kazuhiko Nishida, Shigemiki Omiya, Manabu Taneike, Mara-Camelia Rusu, Yasushi Sakata, Tomokazu Murakawa, Ryuta Sugihara, Kentaro Mine, Hiroki Nishida, Kinya Otsu, Jumpei Ito, Javier Moncayo-Arlandi, Ajay M. Shah, Roland Fleck, Chiaki Nakanishi, Osamu Yamaguchi   +16 more
core   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source