Results 1 to 10 of about 333,256 (300)
MYC Immunohistochemistry Predicts MYC Rearrangements by FISH [PDF]
Frontiers in Oncology, 2017 MYC is the proto-oncogene classically associated with Burkitt lymphoma (BL) located at chromosomal locus 8q24. Rearrangements of MYC are seen in nearly 100% of BL but have been reported in 3–16% of diffuse large B-cell lymphomas (DLBCLs).
Julum Nwanze +5 more
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Incurring municipality’s liabilities under a temporary deficit of a local government unit
Prawo Budżetowe Państwa i Samorządu, 2022 Initiatives taken by municipalities acting as part of the public finance sector units include their ability to undertake financial commitments. This is reflected by the systemic solutions laid down in the Local Self-Government Act of 8 March 1990, the ...
Piotr Myć
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Myc or no Myc, that is the question [PDF]
The EMBO Journal, 2015 The transcription factor c-MYC functions as the master transcription factor for establishing highly active metabolic states in proliferating cells. c-Myc is essential for rapid proliferation of normal cells and has causal relationship with many cancers, including leukemia and lymphoma.
Chun, Chou, Takeshi, Egawa
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MYC Participates In Lipopolysaccharide-Induced Sepsis Via Promoting Cell Proliferation And Inhibiting Apoptosis [PDF]
Cell Journal, 2020 Objective This study aimed to explore the potential mechanism of MYC proto-oncogene, BHLH Transcription Factor (MYC) gene, on sepsis. Materials And Methods In this experimental study, rat-derived H9C2 cardiomyocyte cells were cultured in vitro ...
Yin Li +5 more
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Targeting Glutamine Metabolism in Prostate Cancer
Frontiers in Bioscience-Elite, 2023 Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis through reductive ...
Neil Bhowmick +8 more
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Disease Models & Mechanisms, 2021 Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms.
Takuo Hayashi +21 more
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Journal of Cell Science, 2006 Deregulation of Myc expression is a common feature in cancer and leads to tumor formation in experimental model systems. There are several potential barriers that Myc must overcome in order to promote tumorigenesis, including its propensity to sensitize many cell types to apoptotic cell death. Myc activities appear also to be constrained and fine-tuned
C William, Hooker, Peter J, Hurlin
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Sin3b Interacts with Myc and Decreases Myc Levels [PDF]
Journal of Biological Chemistry, 2014 Myc expression is deregulated in many human cancers. A yeast two-hybrid screen has revealed that the transcriptional repressor Sin3b interacts with Myc protein. Endogenous Myc and Sin3b co-localize and interact in the nuclei of human and rat cells, as assessed by co-immunoprecipitation, immunofluorescence, and proximity ligation assay.
García Sanz, Pablo +10 more
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Cold Spring Harbor Perspectives in Medicine, 2014 The MYC oncoprotein is an essential transcription factor that regulates the expression of many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is important to keep MYC activity in check in normal cells in order to avoid unwanted oncogenic changes.
Amy S, Farrell, Rosalie C, Sears
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Kynurenine: an oncometabolite in colon cancer
Cell Stress, 2020 Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of the serotonin ...
Niranjan Venkateswaran +1 more
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