Results 31 to 40 of about 294,417 (155)
MYC in elongation and repression [PDF]
Nature Reviews Cancer, 2018 Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
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Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs
Cells, 2019 Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity.
Marcela Cristina Robaina +2 more
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Open Life Sciences, 2017 Diverse physiological pathways have been shown to regulate longevity, stress resistance, fecundity and feeding rates, and metabolism in Drosophila. Here we tesed physiological traits in flies with Rheb and Myc- Rheb overexpressed in gut progenitor cells,
Strilbytska Olha M. +5 more
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Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
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Transcription factor competition regulates lysosomal biogenesis and autophagy
Molecular & Cellular Oncology, 2020 “In the field of observation, chance favours only the prepared mind” (Louis Pasteur). This motto seems to have guided our unexpected results published recently in Nature Communications, where we describe an epigenetic rheostat that regulates expression ...
Alessandra d'Azzo, Ida Annunziata
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Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran [PDF]
Middle East Journal of CancerBackground: Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma, characterized by remarkable molecular heterogeneity.
Fatemeh Radmanesh +4 more
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eLife, 2020 The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals.
Tamsin J Samuels +3 more
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Advances in cancer research, 2009 Myc genes play a major role in human cancer, and they are important regulators of growth and proliferation during normal development. Despite intense study over the last three decades, many aspects of Myc function remain poorly understood. The identification of a single Myc homolog in the model organism Drosophila melanogaster more than 10 years ago ...
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Genes & Cancer, 2010 Myc proteins control several cellular processes, including proliferation and growth, and they play an important role in human tumorigenesis. Several years ago, single homologs of Myc, its interaction partner Max, and its antagonist Mnt were identified in Drosophila melanogaster. Here, we review the function of this so-called Max network in fruit flies,
Bellosta, Paola, Gallant, P.
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MYC’s Fine Line Between B Cell Development and Malignancy
Cells, 2020 The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of
Oriol de Barrios +2 more
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