Results 31 to 40 of about 333,256 (300)
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn +26 more
core +1 more source
, 2023 A.MYCN was determined in parental SKNAS, SKNAS N-MYC-ER, or SHEP N-MYC-ER by qPCR in n = 3 replicates by quantitative PCR (qPCR), normalized to β2M. MYCN overexpression is shown relative to parental SKNAS, since SHEP do not express MYCN. B.
Brian J. Altman (16819407) +12 more
core +1 more source
Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
Molecular & Cellular Oncology, 2018 The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
doaj +1 more source
Tuning protein synthesis for cancer therapy
Molecular & Cellular Oncology, 2021 ~50% of colorectal cancers have an activating mutation in KRAS (encoding the KRAS proto-oncogene) and remain difficult to target in the clinic. We have recently shown that activation of KRAS protein alters the regulation of mRNA translation, increasing ...
John R. P. Knight, Owen J. Sansom
doaj +1 more source
The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]
, 2013 The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
Shi, Xiao-Hua +22 more
core +1 more source
myc-BirA*-FOPNL BioID raw protein measurement.
, 2022 MS/MS comparison of 2 biological replicates of the myc-BirA*-FOPNL with the myc-BirA*. High-confidence interactors were defined as those with q value 5. (XLSX)
Anne-Marie Tassin (88902) +13 more
core +1 more source
The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
Cells, 2020 The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer.
Raffaella Pippa, Maria D. Odero
doaj +1 more source
, 2023 Primary Myelofibrosis (PMF) is an aggressive myeloproliferative neoplasm (MPN) characterized by constitutional symptoms, cytopenias, splenomegaly, extramedullary hematopoiesis, bone marrow (BM) fibrosis, and a propensity to transform to acute myeloid ...
Najla H Al Ali (17721657) +24 more
core +1 more source
Chromatin Immunoprecipitation Assays for Myc and N-Myc [PDF]
, 2013 Myc and N-Myc have widespread impacts on the chromatin state within cells, both in a gene-specific and genome-wide manner. Our laboratory uses functional genomic methods including chromatin immunoprecipitation (ChIP), ChIP-chip, and, more recently, ChIP-seq to analyze the binding and genomic location of Myc.
Bonnie L, Barrilleaux +2 more
openaire +2 more sources
Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc
, 2022 Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an
Yongqiang Yang (670525) +9 more
core +1 more source