Results 51 to 60 of about 333,256 (300)
Advances in cancer research, 2009 Myc genes play a major role in human cancer, and they are important regulators of growth and proliferation during normal development. Despite intense study over the last three decades, many aspects of Myc function remain poorly understood. The identification of a single Myc homolog in the model organism Drosophila melanogaster more than 10 years ago ...
openaire +4 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
MYC’s Fine Line Between B Cell Development and Malignancy
Cells, 2020 The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of
Oriol de Barrios +2 more
doaj +1 more source
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Zhongliu Fangzhi Yanjiu, 2020 Objective To investigate the correlation between MYC/BCL2 double-expression large B cell lymphoma (DEL) and programmed cell death ligand 1 (PD-L1) mRNA or protein expressions and analyze the clinical significance of PD-L1 protein expression in DEL ...
WANG Ping +4 more
doaj +1 more source
Myc-dependent and TXNIP-regulated genes in 231:TKO cells are conserved.
, 2023 Related to Fig 5. (A) The Myc binding sites in our Myc ChIP-sequencing in 231:TKO dataset was compared with Myc binding sites in published Myc ChIP-sequencing datasets GSE77356 and GSE126207 [27,42].
Donald E. Ayer (9733888) +8 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
MYC as therapeutic target in leukemia and lymphoma [PDF]
, 2015 MYC is a transcription factor that is involved in the expression of many genes. Deregulated MYC is found in about half of human tumors, being more prevalent in hematological neoplasms.
Albajar Molera, Marta +4 more
core +2 more sources