Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]
PLoS ONE, 2008 The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu +8 more
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WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
Oncogenesis, 2023 Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoting oncogenic gene expression programs in ...
Leigh A. Bumpous +12 more
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N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. [PDF]
PLoS ONE, 2009 myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells.
Rebecca Cotterman, Paul S Knoepfler
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Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. [PDF]
PLoS ONE, 2008 The Myc oncoprotein is a transcription factor involved in a variety of human cancers. Overexpression of Myc is associated with malignant transformation.
Jonghwan Kim +2 more
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Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. [PDF]
PLoS ONE, 2009 BACKGROUND:The Myc oncoprotein, a transcriptional regulator involved in the etiology of many different tumor types, has been demonstrated to play an important role in the functions of embryonic stem (ES) cells.
Chin-Hsing Lin +4 more
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Integration of genome and chromatin structure with gene expression profiles to predict c-MYC recognition site binding and function. [PDF]
PLoS Computational Biology, 2007 The MYC genes encode nuclear sequence specific-binding DNA-binding proteins that are pleiotropic regulators of cellular function, and the c-MYC proto-oncogene is deregulated and/or mutated in most human cancers. Experimental studies of MYC binding to the
Yili Chen +5 more
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Journal of Advanced Research, 2023 Background: Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, MYC is difficult to target because of its undruggable structure.
Sha Li +14 more
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Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis. [PDF]
PLoS Genetics, 2008 The MYC oncogene has been implicated in the regulation of up to thousands of genes involved in many cellular programs including proliferation, growth, differentiation, self-renewal, and apoptosis.
Chi-Hwa Wu +5 more
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Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. [PDF]
PLoS ONE, 2013 Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC.
Maria B Raeder +20 more
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Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. [PDF]
PLoS ONE, 2011 BACKGROUND: MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis.
Volkhard Seitz +13 more
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