Results 41 to 50 of about 1,721,302 (204)

The N-myc gene product in primary retinoblastomas [PDF]

Cancer, 1989
The N-myc gene product in retinoblastomas was examined using the antisera against the N-myc gene product, which was produced as a fusion protein by Escherichia coli. The N-myc gene product was detected not only in the retinoblastoma cell line Y79 but also in primary retinoblastomas as a pair of bands of approximately 62 kilodaltons (KD) by ...
T, Yokoyama, T, Tsukahara, C, Nakagawa, T, Kikuchi, K, Minoda, H, Shimatake   +5 more
openaire   +2 more sources

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

Haematologica, 2020
MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood.
Aneta Mikulasova, Cody Ashby, Ruslana G. Tytarenko, Pingping Qu, Adam Rosenthal, Judith A. Dent, Katie R. Ryan, Michael A. Bauer, Christopher P. Wardell, Antje Hoering, Konstantinos Mavrommatis, Matthew Trotter, Shayu Deshpande, Shmuel Yaccoby, Erming Tian, Jonathan Keats, Daniel Auclair, Graham H. Jackson, Faith E. Davies, Anjan Thakurta, Gareth J. Morgan, Brian A. Walker   +21 more
doaj   +1 more source

Nuclear AXIN2 represses MYC gene expression [PDF]

Biochemical and Biophysical Research Communications, 2014
The β-catenin transcriptional coactivator is the key mediator of the canonical Wnt signaling pathway. In the absence of Wnt, β-catenin associates with a cytosolic and multi-protein destruction complex where it is phosphorylated and targeted for proteasomal degradation.
Sherri A, Rennoll, Wesley M, Konsavage, Gregory S, Yochum   +2 more
openaire   +2 more sources

Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma

Nature Communications
The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CRISPR/Cas9 ...
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher   +11 more
doaj   +1 more source

Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells

Haematologica, 2011
Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. Although the identification of other cooperative genes involved is important, our present understanding of such ...
Masao Nakagawa, Shinobu Tsuzuki, Keiichiro Honma, Osamu Taguchi, Masao Seto   +4 more
doaj   +1 more source

Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

Pharmaceuticals, 2022
Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator pathways could be targeted instead.
Belal Almajali, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Wan Rohani Wan Taib, Imilia Ismail, Maysa Alhawamdeh, Nafe M. Al-Tawarah, Wisam Nabeel Ibrahim, Futoon Abedrabbu Al-Rawashde, Hamid Ali Nagi Al-Jamal   +9 more
doaj   +1 more source

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]

, 2013
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
Shi, Xiao-Hua, Shi, XH, Jacob C. Larkin, Baosheng Chen, Xiao-Hua Shi (2286394), Larkin Jacob C., Larkin, Jacob C., Yoel Sadovsky, Baosheng Chen (294603), Larkin, JC, Chuang, Eric Y., Jacob C Larkin, Chen Baosheng, Sadovsky, Y, Shi Xiao-Hua, Chen, Baosheng, Sadovsky, Yoel, Sadovsky Yoel, Yoel Sadovsky (199874), Jacob C. Larkin (459267), Chen, B, Xiao-Hua Shi, Larkin, Jacob C   +22 more
core   +1 more source

MYC and N-MYC are overexpressed in MYC-ER and N-MYC-ER-expressing cells, and naturally overexpressed MYC controls circadian gene expression.

, 2023
A.MYCN was determined in parental SKNAS, SKNAS N-MYC-ER, or SHEP N-MYC-ER by qPCR in n = 3 replicates by quantitative PCR (qPCR), normalized to β2M. MYCN overexpression is shown relative to parental SKNAS, since SHEP do not express MYCN. B.
Brian J. Altman (16819407), Aalim M. Weljie (244968), Chi V. Dang (9424989), Stephano S. Mello (15101894), Rebekah Brooks (16819404), Siti Noor Ain Binti Ahmad Shahidan (16819392), Zandra E. Walton (16819401), Jamison B. Burchett (9707399), Daniel Mwangi (16819395), Rachel E. DeRollo (16819389), Annie L. Hsieh (16819398), Saikumari Krishnaiah (4433761), Juliana Cazarin (16819386)   +12 more
core   +1 more source

Characteristics and Expression Pattern of MYC Genes in Triticum aestivum, Oryza sativa, and Brachypodium distachyon

Plants, 2019
Myelocytomatosis oncogenes (MYC) transcription factors (TFs) belong to basic helix-loop-helix (bHLH) TF family and have a special bHLH_MYC_N domain in the N-terminal region.
Shoukun Chen, Hongyan Zhao, Tengli Luo, Yue Liu, Xiaojun Nie, Haifeng Li   +5 more
doaj   +1 more source

CRISPR/Cas9 screen for genome‐wide interrogation of essential MYC‐bound E‐boxes in cancer cells

Molecular Oncology, 2023
The transcription factor MYC is a proto‐oncogene with a well‐documented essential role in the pathogenesis and maintenance of several types of cancer.
Marta Kazimierska, Marta Podralska, Magdalena Żurawek, Tomasz Woźniak, Marta Elżbieta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Iwona Ziółkowska‐Suchanek, Joost Kluiver, Anke van denBerg, Natalia Rozwadowska, Agnieszka Dzikiewicz‐Krawczyk   +11 more
doaj   +1 more source