Results 41 to 50 of about 239,792 (215)

Myc represses the growth arrest gene gadd45 [PDF]

Oncogene, 1997
The c-Myc protein strongly stimulates cellular proliferation, inducing cells to exit G0/G1 and enter the cell cycle. At a molecular level, Myc prevents growth arrest and drives cell cycle progression through the transcriptional regulation of Myc-target genes.
W W, Marhin, S, Chen, L M, Facchini, A J, Fornace, L Z, Penn   +4 more
openaire   +2 more sources

Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells

Haematologica, 2011
Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. Although the identification of other cooperative genes involved is important, our present understanding of such ...
Masao Nakagawa, Shinobu Tsuzuki, Keiichiro Honma, Osamu Taguchi, Masao Seto   +4 more
doaj   +1 more source

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

Haematologica, 2020
MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood.
Aneta Mikulasova, Cody Ashby, Ruslana G. Tytarenko, Pingping Qu, Adam Rosenthal, Judith A. Dent, Katie R. Ryan, Michael A. Bauer, Christopher P. Wardell, Antje Hoering, Konstantinos Mavrommatis, Matthew Trotter, Shayu Deshpande, Shmuel Yaccoby, Erming Tian, Jonathan Keats, Daniel Auclair, Graham H. Jackson, Faith E. Davies, Anjan Thakurta, Gareth J. Morgan, Brian A. Walker   +21 more
doaj   +1 more source

Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer. [PDF]

PLoS ONE, 2008
BACKGROUND: Estrogen is a pivotal regulator of cell proliferation in the normal breast and breast cancer. Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired ...
Elizabeth A Musgrove, C Marcelo Sergio, Sherene Loi, Claire K Inman, Luke R Anderson, M Chehani Alles, Mark Pinese, C Elizabeth Caldon, Judith Schütte, Margaret Gardiner-Garden, Christopher J Ormandy, Grant McArthur, Alison J Butt, Robert L Sutherland   +13 more
doaj   +1 more source

Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma

Nature Communications
The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CRISPR/Cas9 ...
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher   +11 more
doaj   +1 more source

Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

Pharmaceuticals, 2022
Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator pathways could be targeted instead.
Belal Almajali, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Wan Rohani Wan Taib, Imilia Ismail, Maysa Alhawamdeh, Nafe M. Al-Tawarah, Wisam Nabeel Ibrahim, Futoon Abedrabbu Al-Rawashde, Hamid Ali Nagi Al-Jamal   +9 more
doaj   +1 more source

Identifying Genes Regulated in a Myc-dependent Manner [PDF]

Journal of Biological Chemistry, 2002
The c-myc proto-oncogene can direct a diverse array of biological activities, including cell cycle progression, apoptosis, and differentiation. It is believed that Myc can affect this wide variety of activities by functioning as a regulator of gene transcription, although few targets have been identified to date.
John D, Watson, Sara K, Oster, Mary, Shago, Fereshteh, Khosravi, Linda Z, Penn   +4 more
openaire   +2 more sources

Characteristics and Expression Pattern of MYC Genes in Triticum aestivum, Oryza sativa, and Brachypodium distachyon

Plants, 2019
Myelocytomatosis oncogenes (MYC) transcription factors (TFs) belong to basic helix-loop-helix (bHLH) TF family and have a special bHLH_MYC_N domain in the N-terminal region.
Shoukun Chen, Hongyan Zhao, Tengli Luo, Yue Liu, Xiaojun Nie, Haifeng Li   +5 more
doaj   +1 more source

CRISPR/Cas9 screen for genome‐wide interrogation of essential MYC‐bound E‐boxes in cancer cells

Molecular Oncology, 2023
The transcription factor MYC is a proto‐oncogene with a well‐documented essential role in the pathogenesis and maintenance of several types of cancer.
Marta Kazimierska, Marta Podralska, Magdalena Żurawek, Tomasz Woźniak, Marta Elżbieta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Iwona Ziółkowska‐Suchanek, Joost Kluiver, Anke van denBerg, Natalia Rozwadowska, Agnieszka Dzikiewicz‐Krawczyk   +11 more
doaj   +1 more source

Normal and Neoplastic Growth Suppression by the Extended Myc Network

Cells, 2022
Among the first discovered and most prominent cellular oncogenes is MYC, which encodes a bHLH-ZIP transcription factor (Myc) that both activates and suppresses numerous genes involved in proliferation, energy production, metabolism and translation.
Edward V. Prochownik, Huabo Wang
doaj   +1 more source