Results 51 to 60 of about 1,721,302 (204)
Normal and Neoplastic Growth Suppression by the Extended Myc Network
Cells, 2022 Among the first discovered and most prominent cellular oncogenes is MYC, which encodes a bHLH-ZIP transcription factor (Myc) that both activates and suppresses numerous genes involved in proliferation, energy production, metabolism and translation.
Edward V. Prochownik, Huabo Wang
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Positive and negative regulation of Myc-mediated transcription [PDF]
, 2008 The aim of this thesis has been focused to analyze the positive regulation of Myc-mediated transcription by P-TEFb elongation complex, and the negative control exerted by p14ARF onco-suppressor on Myc's transactivation functions.
Gargano, Barbara
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BMC GenomicsBackground Myelocytomatosis (MYC) transcription factors are crucial mediators of the response of plants to environmental stresses through via binding to DNA regulatory regions.
Tao Liu +8 more
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Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs. [PDF]
PLoS ONE, 2013 Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs).
Masataka Hirasaki +6 more
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Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs
Cells, 2019 Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity.
Marcela Cristina Robaina +2 more
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Frontiers in Genetics, 2022 MYC is one of the well-known oncogenes, and its important role in cancer still remains largely unknown. We obtained lung adenocarcinoma (LUAD) multi-omics data including genome, transcriptome, and single-cell sequencing data from multiple cohorts.
Lu Hao, Qiuyan Chen, Xi Chen, Qing Zhou
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Organization and expression of the chicken N-myc gene. [PDF]
Molecular and Cellular Biology, 1990 We cloned the chicken N-myc gene and analyzed its structure and expression. We found that it consisted of three exons with coding regions in exons 2 and 3. Comparison to mammalian N-myc genomic sequence indicated that nucleotide sequences of the 5'-flanking region, noncoding exon 1, and introns were not conserved, but coding and 3' noncoding sequences ...
S, Sawai +3 more
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Identifying Genes Regulated in a Myc-dependent Manner [PDF]
Journal of Biological Chemistry, 2002 The c-myc proto-oncogene can direct a diverse array of biological activities, including cell cycle progression, apoptosis, and differentiation. It is believed that Myc can affect this wide variety of activities by functioning as a regulator of gene transcription, although few targets have been identified to date.
John D, Watson +4 more
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c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]
, 2007 Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Rachel G. Berkson +2 more
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Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer
Journal of Ovarian ResearchOvarian cancer remains one of the most lethal gynecological malignancies owing to its high recurrence rate and chemotherapeutic resistance. MYC is a well-known proto-oncogene that is frequently amplified in ovarian cancer and has been implicated in drug ...
Akiko Yamamoto +7 more
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