Results 71 to 80 of about 1,721,302 (204)

Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc

, 2022
Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an
Yongqiang Yang (670525), Wencai Li (3942530), Yingjuan Zheng (12110814), Lei Wang (6656), Xinqiang Li (2554165), Qing Zhang (1802), Xiaole Li (4496476), Daoke Yang (9294902), Shichao Duan (12110811), Rick F. Thorne (11680261)   +9 more
core   +1 more source

Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus

BMC Genomics
Background During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impaired, leading ...
Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller   +9 more
doaj   +1 more source

Transcriptional regulation of prostate kallikrein-like genes by androgen. [PDF]

, 1992
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied.
Schulz, Peter, Fittler, Friedrich, Wolf, Dieter A.   +2 more
core   +1 more source

Cazarin and Derollo et al Figure 3 and Supplemental Figure 3: SHEP N-MYC-ER Phase Set Enrichment Analysis (PSEA) ResultsSource data for MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

, 2023
Source data from Phase Set Enrichment Analysis (PSEA) of oscillating genes from SHEP N-MYC-ER OFF and ON.
Brian J. Altman (16819407), Aalim M. Weljie (244968), Chi V. Dang (9424989), Brian Altman (14202566), Stephano S. Mello (15101894), Rebekah Brooks (16819404), Siti Noor Ain Binti Ahmad Shahidan (16819392), Zandra E. Walton (16819401), Jamison B. Burchett (9707399), Daniel Mwangi (16819395), Rachel E. DeRollo (16819389), Annie L. Hsieh (16819398), Saikumari Krishnaiah (4433761), Juliana Cazarin (16819386), Brian Altman (17117536)   +14 more
core   +1 more source

Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]

The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
core  

Cazarin and Derollo et al Figure 3 and Supplemental Figure 3: SKNAS N-MYC-ER Phase Set Enrichment Analysis (PSEA) ResultsSource data for MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

, 2023
 Source data from Phase Set Enrichment Analysis (PSEA) of oscillating genes from SKNAS N-MYC-ER OFF and ON. 
Brian J. Altman (16819407), Aalim M. Weljie (244968), Chi V. Dang (9424989), Brian Altman (14202566), Stephano S. Mello (15101894), Rebekah Brooks (16819404), Siti Noor Ain Binti Ahmad Shahidan (16819392), Zandra E. Walton (16819401), Jamison B. Burchett (9707399), Daniel Mwangi (16819395), Rachel E. DeRollo (16819389), Annie L. Hsieh (16819398), Saikumari Krishnaiah (4433761), Juliana Cazarin (16819386), Brian Altman (17117536)   +14 more
core   +1 more source

Modeling and Targeting MYC Genes in Childhood Brain Tumors

, 2017
Brain tumors are the second most common group of childhood cancers, accounting for about 20%-25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of ...
Hutter, Sonja, Bolin, Sara, Sara Bolin, Johansson, Fredrik K.,, Hutter, Sonja,, Sonja Hutter, Fredrik Swartling, Bolin, Sara,, Weishaupt, Holger,, Weishaupt, Holger, Johansson, Fredrik K., Holger Weishaupt   +11 more
core   +1 more source

Target gene-independent functions of MYC oncoproteins

Nature Reviews Molecular Cell Biology, 2020
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large body of evidence indicates that MYC proteins are transcription factors, studying their function has focused on the biology of their target genes. Detailed studies of MYC-dependent changes in RNA levels have provided contrasting models of the oncogenic activity of MYC
Apoorva Baluapuri, Elmar Wolf, Martin Eilers   +2 more
openaire   +3 more sources

MicroRNA profiling in B cell non-Hodgkin Lymphoma : focus on the role of MYC [PDF]

, 2013
Non-Hodgkinlymfoon is een kwaadaardige vorm van kanker die uitgaat van de lymfeklieren. De ziekte wordt gekenmerkt door specifieke chromosoomafwijkingen en door afwijkende patronen van genexpressie.
Robertus, Jan Lukas,, Robertus, Jan Lukas   +1 more
core   +1 more source

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity [PDF]

, 1997
The c-myc gene encodes a sequence-specific DNA binding protein involved in proliferation and oncogenesis. Activation of c-myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of c-myc expression causes cycling ...
Bernards, R.A., Hijmans, E.M., Berns, K.
core   +1 more source