Results 71 to 80 of about 239,792 (215)
EMBO Molecular Medicine, 2014 Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF‐BP1, MULE) associates with both MYC and the MYC‐associated protein MIZ1.
Stefanie Peter +16 more
doaj +1 more source
Modeling and Targeting MYC Genes in Childhood Brain Tumors
, 2017 Brain tumors are the second most common group of childhood cancers, accounting for about 20%-25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of ...
Hutter, Sonja +11 more
core +1 more source
MicroRNA profiling in B cell non-Hodgkin Lymphoma : focus on the role of MYC [PDF]
, 2013 Non-Hodgkinlymfoon is een kwaadaardige vorm van kanker die uitgaat van de lymfeklieren. De ziekte wordt gekenmerkt door specifieke chromosoomafwijkingen en door afwijkende patronen van genexpressie.
Robertus, Jan Lukas, +1 more
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Detection of MYC gene amplification in malignant lymphomas [PDF]
Journal of Korean Medical Science, 1998 The role of oncogene or tumor supressor gene in Epstein-Barr virus (EBV) associated malignant lymphomas (MLs) is poorly understood. We examined 36 MLs (21 EBV positive and 15 EBV negative) and 6 reactive hyperplasias for the presence of myc gene amplification.
C K, Park, C G, Lee, J D, Lee
openaire +2 more sources
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
BMC GenomicsBackground During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impaired, leading ...
Sarah A. Streeter +9 more
doaj +1 more source
Gene Expression in Neuroblastoma [PDF]
, 1996 The aim of this project is to identify potential target genes (NTG's) which may be regulated by in the cell line SK-N-SH which has no amplification of theoncogene N-myc.
Said, Sohair S.S.
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Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]
The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
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Molecular and functional characterization of the interaction between c-Myc and the MCM helicase
, 2006 The Myc genes (c-myc, n-myc, l-myc, s-myc) encode a family of protein that share structural an biological features and are conserved across all Metazoans.
Ruggiero, Luca
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MYC inhibits migration of lung cancer cell lines by down-regulating AKR1C1 expression [PDF]
Jichu yixue yu linchuangObjective To explore the role of MYC in lung cancer cell migration and reveal the mechanism affecting migration. Methods siRNA MYC or pRK5-MYC plasmid was transfected into lung cancer cells A549. Cell migration was examined by wound healing assay.
JIA Kun, ZHOU Yanyan
doaj +1 more source
, 2007 Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Rachel G. Berkson +2 more
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