Results 91 to 100 of about 239,792 (215)

Identification of novel genes involved in the commitment of endodermal cells to the thymic epithelial cell fate [PDF]

, 2006
The thymus provides the microenvironment for the maturation and selection of the majority of peripheral T cells. Endodermal cells of the ventral aspect of the third pharyngeal pouch (3rdpp) at 10.5 days of mouse gestation (E10.5) adopt a thymic ...
Mathieu, Yves D.
core   +1 more source

Identification of key genes related to lymphangiogenesis in venous thromboembolism through transcriptomics and verification by RT-qPCR

Frontiers in Medicine
BackgroundVenous thromboembolism (VTE), a life-threatening cardiovascular disorder, involves complex interactions between thrombosis and immune dysregulation. Lymphangiogenesis-related genes (LRGs) may directly induce thrombosis by regulating endothelial
Yusheng Lin, Yusheng Lin, Jiahan Wu, Pucheng Wang, Xiaodong Lin, Hongwei Yang, Hongwei Yang   +6 more
doaj   +1 more source

Control of Cell Proliferation by Myc Family Genes

Molecules and Cells, 1999
The c-myc proto-oncogene was discovered as the cellular homologue of the transforming oncogene of several chicken retroviruses. It has become clear that c-myc is a member of a small gene family; members of this family encode transcription factors of the Helix-loop-Helix family of transcription factors that can both activate and repress transcription ...
openaire   +2 more sources

Alteraciones del gen c-Myc en la oncogénesis = c-Myc gene alterations in oncogenesis

Iatreia, 2011
La familia de protooncogenes MYC (c-Myc, N-Myc y L-Myc) se relaciona con el origen de diversas neoplasias en seres humanos. Estos genes actúan como factores de transcripción y participan en la regulación del ciclo celular, la proliferación y ...
Ospina Pérez, Mariano, Muñetón Peña, Carlos Mario   +1 more
doaj  

Endogenous Myc maintains the tumor microenvironment

, 2011
The ubiquitous deregulation of Myc in human cancers makes it an intriguing therapeutic target, a notion supported by recent studies in Ras-driven lung tumors showing that inhibiting endogenous Myc triggers ubiquitous tumor regression.
Swigart, Lamorna Brown, Anthony N. Karnezis, Sodir, Nicole M., Nicole M. Sodir, Lamorna Brown Swigart, Karnezis, Anthony N., Douglas Hanahan, Hanahan, Douglas, Evan, Gerard I., Laura Soucek, Soucek, Laura, Gerard I. Evan   +11 more
core   +1 more source

Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus

, 2009
Squamous cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where the incidence is frequently high and access to health care facilities is often limited.
Bracher, Jacqueline Claire
core  

The Human myc Gene Family

Cold Spring Harbor Symposia on Quantitative Biology, 1986
F W, Alt, R, DePinho, K, Zimmerman, E, Legouy, K, Hatton, P, Ferrier, A, Tesfaye, G, Yancopoulos, P, Nisen   +8 more
openaire   +2 more sources

Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer

Translational Oncology
MYC amplification is disproportionally elevated in triple-negative breast cancer (TNBC) compared to other subtypes of breast cancer. Indeed, MYC has long been considered an undruggable oncogene using conventional drug design strategies or small molecules.
Negesse Mekonnen, Hobin Yang, Nirmal Rajasekaran, Kyoung Song, Yoon-La Choi, Young Kee Shin   +5 more
doaj   +1 more source

Functional analysis of N-MYC downstream regulated gene 1 (NDRG1) in Oesophageal squamous cell carcinoma

, 2009
Oesophageal squamous cell carcinoma (OSCC) ranks as one of the deadliest tumours with a high incidence in developing countries in the areas of Southern Africa, Middle East and Far East.
Wei, Wei
core  

MYC Gene [PDF]

, 2020
openaire   +1 more source