Results 81 to 90 of about 239,792 (215)
Multi-scale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers [PDF]
, 2015 This work was partially funded by the Strategic Educational Pathways Scholarship (Malta). The scholarship is part-financed by the European Union – European Social Fund (ESF) under Operational Programme II – Cohesion Policy 2007-2013, “Empowering People ...
Briffa, Romina +23 more
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The Promyelocytic Leukaemia gene product PML interacts with Myc and influences the expression of Myc target genes [PDF]
, 2004 c-myc is a well-known proto-oncogene encoding a transcription factor that needs to be tightly regulated in order to preserve cell homeostasis. The Promyelocytic Leukaemia gene product PML plays an important role in cell growth and survival, and resides in discrete sub-nuclear structures called Nuclear Bodies (NB).
openaire +1 more source
The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression [PDF]
, 2011 G-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream ...
Stebbeds, William Joshua David
core
, 1997 The c-myc gene encodes a sequence-specific DNA binding protein involved in proliferation and oncogenesis. Activation of c-myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of c-myc expression causes cycling ...
Bernards, R.A., Hijmans, E.M., Berns, K.
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Transcriptional regulation of the human c-myc gene
, 1988 The involvement of c-myc in the genesis of animal neoplasia is now well documented for several systems. In order to define the precise role played by the myc gene in tumorigenesis, a better understanding of the normal regulation of myc expression is ...
Wilkie, N M +3 more
core
Positive and negative regulation of Myc-mediated transcription
, 2008 The aim of this thesis has been focused to analyze the positive regulation of Myc-mediated transcription by P-TEFb elongation complex, and the negative control exerted by p14ARF onco-suppressor on Myc's transactivation functions.
Gargano, Barbara
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Acta Neuropathologica CommunicationsMYC dysregulation is pivotal in the onset and progression of IDH-mutant gliomas, mostly driven by copy-number alterations, regulatory element alterations, or epigenetic changes.
Ege Ülgen +6 more
doaj +1 more source
GSEA of MYC target genes in tumors characterized for MYC protein expression;
, 2012 (A). Gene Set Enrichment Analysis (GSEA) of all primary DLBCL cases reveals coordinate upregulation of MYC and MYC target genes (black vertical lines) in tumors with >50% MYC positive tumor nuclei (including MYC translocation-positive and –negative cases)
Margaret A. Shipp (171976) +9 more
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, 2013 The preimplantation mammalian embryo is sensitive to the environment in which they develop and grow, either in vivo or in vitro. Disturbance to embryo environmental conditions can affect embryo growth.
Bakheet, Ayat
core
Inducible expression of Myc defines Myc-responsive and Myc-unresponesive Ikaros target genes.
, 2019 (A) Expression of Ikaros-ERt2 and Myc-ERt2 in B3 cells as detected by western blotting. (B) Chromatin RNA-seq showed that the expression of 2,809 genes was regulated by Myc (adj. P P P values are indicated.
Vincenzo Lagani (3331419) +23 more
core +1 more source