Results 61 to 70 of about 1,721,302 (204)
The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression [PDF]
, 2011 G-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream ...
Stebbeds, William Joshua David
core +2 more sources
The mych gene is required for neural crest survival during zebrafish development. [PDF]
PLoS ONE, 2008 Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any ...
Sung-Kook Hong +2 more
doaj +1 more source
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth
Clinical and Translational Medicine, 2023 Background The MYC oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others.
Yan Xiong +12 more
doaj +1 more source
Cell Communication and Signaling, 2023 Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6 genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the protein products of these three genes in cancer malignancy and immune ...
Hisataka Sabe
doaj +1 more source
N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.
PLoS ONE, 2012 Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre.
Verónica Martínez-Cerdeño +6 more
doaj +1 more source
Detection of MYC gene amplification in malignant lymphomas [PDF]
Journal of Korean Medical Science, 1998 The role of oncogene or tumor supressor gene in Epstein-Barr virus (EBV) associated malignant lymphomas (MLs) is poorly understood. We examined 36 MLs (21 EBV positive and 15 EBV negative) and 6 reactive hyperplasias for the presence of myc gene amplification.
C K, Park, C G, Lee, J D, Lee
openaire +2 more sources
EMBO Molecular Medicine, 2014 Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF‐BP1, MULE) associates with both MYC and the MYC‐associated protein MIZ1.
Stefanie Peter +16 more
doaj +1 more source
The quest for targets executing MYC-dependent cell transformation
Frontiers in Oncology, 2016 MYC represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding RNAs important for cell proliferation,
Markus eHartl
doaj +1 more source
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC
Cell Communication and Signaling, 2023 Background When ectopically overexpressed, anticancer genes, such as TRAIL, PAR4 and ORCTL3, specifically destroy tumour cells without harming untransformed cells. Anticancer genes can not only serve as powerful tumour specific therapy tools but studying
Motasim Masood +6 more
doaj +1 more source
The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye +15 more
core +1 more source