The mych gene is required for neural crest survival during zebrafish development. [PDF]
PLoS ONE, 2008 Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any ...
Sung-Kook Hong +2 more
doaj +1 more source
C-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations [PDF]
, 1984 We have determined the localization of c-myc and the immunoglobulin kappa light chain genes on the 8q+/2p- chromosomes of the three Burkitt lymphoma lines BL21, LY66 and LY91 with t(2;8) translocation by in situ hybridization.
Cremer, Thomas +7 more
core
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
core +1 more source
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth
Clinical and Translational Medicine, 2023 Background The MYC oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others.
Yan Xiong +12 more
doaj +1 more source
MYC as therapeutic target in leukemia and lymphoma [PDF]
, 2015 MYC is a transcription factor that is involved in the expression of many genes. Deregulated MYC is found in about half of human tumors, being more prevalent in hematological neoplasms.
Albajar Molera, Marta +4 more
core +2 more sources
Organization and expression of the chicken N-myc gene. [PDF]
Molecular and Cellular Biology, 1990 We cloned the chicken N-myc gene and analyzed its structure and expression. We found that it consisted of three exons with coding regions in exons 2 and 3. Comparison to mammalian N-myc genomic sequence indicated that nucleotide sequences of the 5'-flanking region, noncoding exon 1, and introns were not conserved, but coding and 3' noncoding sequences ...
S, Sawai +3 more
openaire +2 more sources
N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.
PLoS ONE, 2012 Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre.
Verónica Martínez-Cerdeño +6 more
doaj +1 more source
Cell Communication and Signaling, 2023 Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6 genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the protein products of these three genes in cancer malignancy and immune ...
Hisataka Sabe
doaj +1 more source
The quest for targets executing MYC-dependent cell transformation
Frontiers in Oncology, 2016 MYC represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding RNAs important for cell proliferation,
Markus eHartl
doaj +1 more source
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC
Cell Communication and Signaling, 2023 Background When ectopically overexpressed, anticancer genes, such as TRAIL, PAR4 and ORCTL3, specifically destroy tumour cells without harming untransformed cells. Anticancer genes can not only serve as powerful tumour specific therapy tools but studying
Motasim Masood +6 more
doaj +1 more source