Results 101 to 110 of about 239,792 (215)

MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications

Haematologica
The current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies.
Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, Kai Fu   +13 more
doaj   +1 more source

Identification of MYC synthetic lethal genes and networks

SUMMARY MYC is a potent oncogene that is frequently overexpressed in human tumors arising in different tissues. To date there are no approved therapies to directly antagonize oncogenic MYC and its role in driving tumorigenesis. As an alternative approach we employed genetic screens using CRISPR and shRNA to identify the genes that are ...
Timothy D. Martin, Mei Yuk Choi, Rupesh Patel, Anthony Liang, Mamie Z. Li, Stephen J. Elledge   +5 more
openaire   +2 more sources

Gene model for the ortholog of Myc in Drosophila eugracilis

microPublication biology
Gene model for the ortholog of Myc (Myc) in the D. eugracilis Apr. 2013 (BCM-HGSC/Deug_2.0) (DeugGB2) Genome Assembly (GenBank Accession: GCA_000236325.2) of Drosophila eugracilis. This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus ...
Lawson, Megan E., Hoffman, Alexa, Wellik, Isabel G., Thompson, Jeffrey S., Stamm, Joyce, Rele, Chinmay P.   +5 more
openaire   +2 more sources

MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription.

PLoS Biology
MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood.
Zhihui Liu, Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei, Jack F Shern, Carol J Thiele   +7 more
doaj   +1 more source

MYC Gene Amplification [PDF]

, 2020
openaire   +1 more source

MYC Gene Rearrangement [PDF]

, 2020
openaire   +1 more source

Gene model for the ortholog Myc in Drosophila ananassae.

microPublication biology
Gene model for the ortholog of Myc ( Myc ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of Drosophila ananassae . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus Drosophila ...
Myers, Abigail, Hoffman, Alexa, Natysin, Mindy, Arsham, Andrew M, Stamm, Joyce, Thompson, Jeffrey S., Rele, Chinmay P., Reed, Laura K   +7 more
openaire   +2 more sources

Identification of c-Myc responsive genes using rat cDNA microarray

, 2000
c-Myc functions through direct activation or repression of transcription. Using cDNA microarray analysis, we have identified c-Myc-responsive genes by comparing gene expression profiles between c-myc null and c-myc wild-type rat fibroblast cells and ...
Liu, Edison T., Chiao, Chia, He, Mei, Lee, Norman H., Dang, Chi V., Kim, Sunkyu, Guo, Qingbin M., Malek, Renae L., Ruffy, Mauro, Sanka, Krishna   +9 more
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MYC Family Gene [PDF]

, 2020
openaire   +1 more source

An immunohistochemical study of beta-catenin in HNPCC colon tumours

, 2004
Includes bibliographical references (leaves 49-55).Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane.
Watkins, Jennifer G
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