MYC-Alarmin Axis As a Novel Oncogenic Driver in a Subgroup of Triple Negative Myeloproliferative Neoplasms [PDF]
, 2023 Primary Myelofibrosis (PMF) is an aggressive myeloproliferative neoplasm (MPN) characterized by constitutional symptoms, cytopenias, splenomegaly, extramedullary hematopoiesis, bone marrow (BM) fibrosis, and a propensity to transform to acute myeloid ...
Najla H Al Ali (17721657) +24 more
core +1 more source
Myc represses the growth arrest gene gadd45 [PDF]
Oncogene, 1997 The c-Myc protein strongly stimulates cellular proliferation, inducing cells to exit G0/G1 and enter the cell cycle. At a molecular level, Myc prevents growth arrest and drives cell cycle progression through the transcriptional regulation of Myc-target genes.
W W, Marhin +4 more
openaire +2 more sources
Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]
, 2014 This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik +43 more
core +2 more sources
Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma
Acta Neuropathologica Communications, 2020 Medulloblastoma, a highly malignant pediatric brain tumor, consists of four molecular subgroups, namely WNT, SHH, Group 3, and Group 4. The expression of miR-193a, a WNT subgroup-specific microRNA, was found to be induced by MYC, an oncogenic target of ...
Harish Shrikrishna Bharambe +4 more
doaj +1 more source
Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer. [PDF]
PLoS ONE, 2008 BACKGROUND: Estrogen is a pivotal regulator of cell proliferation in the normal breast and breast cancer. Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired ...
Elizabeth A Musgrove +13 more
doaj +1 more source
Myc-dependent and TXNIP-regulated genes in 231:TKO cells are conserved.
, 2023 Related to Fig 5. (A) The Myc binding sites in our Myc ChIP-sequencing in 231:TKO dataset was compared with Myc binding sites in published Myc ChIP-sequencing datasets GSE77356 and GSE126207 [27,42].
Donald E. Ayer (9733888) +8 more
core +1 more source
Cells, 2021 Canines are useful in mammalian preclinical studies because they are larger than rodents and share many diseases with humans. Canine fetal fibroblast cells (CFFs) are an easily accessible source of somatic cells.
So Hee Kim +6 more
doaj +1 more source
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
core +1 more source
C-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations [PDF]
, 1984 We have determined the localization of c-myc and the immunoglobulin kappa light chain genes on the 8q+/2p- chromosomes of the three Burkitt lymphoma lines BL21, LY66 and LY91 with t(2;8) translocation by in situ hybridization.
Cremer, Thomas +7 more
core +1 more source
Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). [PDF]
PLoS ONE, 2010 We investigated mTOR regulation of gene expression by studying rapamycin effect in two hepatic cell lines, the non-tumorigenic WB-F344 cells and the tumorigenic WB311 cells.
Rosa H Jimenez +7 more
doaj +1 more source