Results 21 to 30 of about 239,792 (215)

The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. [PDF]

Genes & Development, 1987
We have determined the nucleotide sequence and transforming activity of the human L-myc gene and a processed L-myc pseudogene (L-myc psi). We demonstrate by cotransformation assays that a 10.6-kb EcoRI fragment derived from a human placental library contains a complete and functional L-myc gene including transcriptional regulatory sequences sufficient ...
R A, DePinho, K S, Hatton, A, Tesfaye, G D, Yancopoulos, F W, Alt   +4 more
openaire   +2 more sources

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

eLife, 2018
As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper ‘Transcriptional amplification in tumor cells with elevated c ...
L Michelle Lewis, Meredith C Edwards, Zachary R Meyers, C Conover Talbot Jr, Haiping Hao, David Blum, Reproducibility Project: Cancer Biology   +6 more
doaj   +1 more source

c-Myc regulates self-renewal in bronchoalveolar stem cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Bronchoalveolar stem cells (BASCs) located in the bronchoalveolar duct junction are thought to regenerate both bronchiolar and alveolar epithelium during homeostatic turnover and in response to injury. The mechanisms directing self-renewal in
Jie Dong, Shari Sutor, Guoqian Jiang, Yajun Cao, Yan W Asmann, Dennis A Wigle   +5 more
doaj   +1 more source

MYC is a metastasis gene for non-small-cell lung cancer. [PDF]

, 2009
Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn, Emanuele Zanucco, Potapenko, Tamara, Korn, C., Zanucco, E., Castro, I., Inês Castro, Fatih Ceteci, Potapenko, T., Ceteci, F., Rapp, Ulf R., Luetkenhaus, Katharina, Ulf R Rapp, Korn, Christian, Tamara Potapenko, Serafin, V., Christiaan Karreman, Castro, Inês, Luetkenhaus, K., Ceteci, Fatih, Zanucco, Emanuele, Valentina Serafin, Karreman, Christiaan, Karreman, C., Serafin, Valentina, Katharina Luetkenhaus, Rapp, U. R.   +26 more
core   +1 more source

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells

Epigenetics & Chromatin, 2011
Background A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important open topic.
Varlakhanova Natalia, Cotterman Rebecca, Bradnam Keith, Korf Ian, Knoepfler Paul S   +4 more
doaj   +1 more source

Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma [PDF]

Journal of Korean Medical Science, 1993
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79, to detect the molecular alterations of the retinoblastoma susceptibility gene (RB-1) and N-myc gene.
S W, Choi, T W, Lee, S W, Yang, W S, Hong, C M, Kim, J O, Lee   +5 more
openaire   +2 more sources

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik, Inga Müller, Oliynyk, G, Ganna Oliynyk (568258), Zirath Hanna, Prochownik Edward V., Larsson, Karin, Anna Frenzel, Marie Arsenian Henriksson, Anna Frenzel (194997), Edward V. Prochownik (163628), Henriksson, MA, Westwood Nicholas J., Oliynyk, Ganna, Hanna Zirath, Marie Arsenian Henriksson (195006), Oliynyk Ganna, Ganna Oliynyk, Larsson, K, Frenzel, A, Frenzel, Anna, Zirath, Hanna, Prochownik, Edward V., Nicholas J Westwood, Frenzel Anna, Zirath, H, Henriksson Marie Arsenian, Karin Larsson, Muller, Inga, Nicholas J. Westwood, Inga Müller (568256), Nicholas J. Westwood (254891), Edward V. Prochownik, Müller, I, Westwood, NJ, Müller Inga, Henriksson, Marie Arsenian, Karin Larsson (568257), Hanna Zirath (195000), Prochownik, EV, Westwood, Nicholas J., Larsson Karin   +41 more
core   +1 more source

A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response.

PLoS ONE, 2009
BackgroundThe MYC oncogene contributes to induction and growth of many cancers but the full spectrum of the MYC transcriptional response remains unclear.Methodology/principal findingsUsing microarrays, we conducted a detailed kinetic study of genes that ...
Sanjay Chandriani, Eirik Frengen, Victoria H Cowling, Sarah A Pendergrass, Charles M Perou, Michael L Whitfield, Michael D Cole   +6 more
doaj   +1 more source

Myc-dependent and TXNIP-regulated genes in 231:TKO cells are conserved.

, 2023
Related to Fig 5. (A) The Myc binding sites in our Myc ChIP-sequencing in 231:TKO dataset was compared with Myc binding sites in published Myc ChIP-sequencing datasets GSE77356 and GSE126207 [27,42].
Donald E. Ayer (9733888), Jason Gertz (18707), Tian-Yeh Lim (14808976), Blake R. Wilde (9733885), Megan E. Conway (4107658), Katherine E. Varley (10652336), Kristin E. Murphy (3132771), Jeffery M. Vahrenkamp (14808982), Mallory L. Thomas (14808979)   +8 more
core   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source