Results 1 to 10 of about 290,504 (118)

Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression [PDF]

MedComm
The c‐MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression.
Yuanyuan Xue, Hao Jiang, Zhaoyun Zong, Xiaolin Tian, Zelong Miao, Ting Li, Yali Wei, Haiteng Deng   +7 more
doaj   +2 more sources

ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC [PDF]

Frontiers in Oncology
Zinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability.
Grania Christyani, Chenghui Cai, Yening Feng, Hyorin Lee, Xinyi Tu, Chao Zhang, Zhenkun Lou, Wootae Kim   +7 more
doaj   +2 more sources

Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma

Frontiers in Oncology, 2022
BackgroundMany studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.MethodsSeveral biological databases, including UALCAN, TIMER2.0 ...
Sufeng Zhao, Li An, Xudong Yang, Zheng Wei, He Zhang, Yufeng Wang   +5 more
doaj   +1 more source

Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8

Cancer Biology & Therapy, 2022
Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases.
Sagar Bajpai, Hong Ri Jin, Bartosz Mucha, J. Alan Diehl   +3 more
doaj   +1 more source

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

Acta Pharmaceutica Sinica B, 2022
The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes.
Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao   +10 more
doaj   +1 more source

Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

Scientific Reports, 2023
c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear.
Takahiro Masaki, Makoto Habara, Shunsuke Hanaki, Yuki Sato, Haruki Tomiyasu, Yosei Miki, Midori Shimada   +6 more
doaj   +1 more source

Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

Cell Communication and Signaling, 2022
Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance.
Ruosi Yao, Menghui Zhang, Jian Zhou, Linlin Liu, Yan Zhang, Jian Gao, Kailin Xu   +6 more
doaj   +1 more source

Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]

PLoS ONE, 2012
We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita, Hirotake Kitaura, Ayako Torii, Erika Tashiro, Makoto Miyazawa, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga   +6 more
doaj   +1 more source

Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc

International Journal of Hyperthermia, 2022
Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li, Shichao Duan, Yingjuan Zheng, Yongqiang Yang, Lei Wang, Xinqiang Li, Qing Zhang, Rick F. Thorne, Wencai Li, Daoke Yang   +9 more
doaj   +1 more source

Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]

PLoS ONE, 2008
The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu, Feng Li, Jesse Handler, Cheng Ran Lisa Huang, Yan Xiang, Nicola Neretti, John M Sedivy, Karen I Zeller, Chi V Dang   +8 more
doaj   +1 more source