PLoS ONE, 2012 BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by ...
Frank M Lehmann +9 more
doaj +5 more sources
Palmitic acid activates c-Myc via dual palmitoylation-dependent pathways to promote colon cancer [PDF]
Cell Discoveryc-Myc is broadly hyperactivated in colon cancer, yet the mechanisms sustaining its transcriptional activation remain elusive. Here we identify palmitic acid (PA) as a metabolite cue that activates c-Myc via dual palmitoylation-dependent pathways ...
Wenxin Du +8 more
doaj +2 more sources
Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression [PDF]
MedCommThe c‐MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression.
Yuanyuan Xue +7 more
doaj +2 more sources
ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC [PDF]
Frontiers in OncologyZinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability.
Grania Christyani +7 more
doaj +2 more sources
LINC01963 promotes pancreatic ductal adenocarcinoma proliferation via METTL3/IGF2BP2 axis-mediated m⁶A modification of c-Myc [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground C-Myc overexpression is an important molecular hallmark of pancreatic ductal adenocarcinoma (PDAC), but directly targeting c-Myc is extremely challenging.
Qixian Liu +15 more
doaj +2 more sources
lncRNA ch-MYC-AS1 restricts ALV-J replication by disrupting the ANXA2-C-Myc oncogenic axis [PDF]
Microbiology SpectrumThe c-Myc oncogene is a critical regulator of viral oncogenesis and immune evasion in multiple cancers. However, its modulation by long noncoding RNAs (lncRNAs) during retroviral infection remains poorly understood. Here, we show that ch-MYC-AS1, a novel
Suyu Fan +8 more
doaj +2 more sources
Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma
Frontiers in Oncology, 2022 BackgroundMany studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.MethodsSeveral biological databases, including UALCAN, TIMER2.0 ...
Sufeng Zhao +5 more
doaj +1 more source
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8
Cancer Biology & Therapy, 2022 Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases.
Sagar Bajpai +3 more
doaj +1 more source
Translocations involving c-myc and c-myc function [PDF]
Oncogene, 2001 c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed.
L M, Boxer, C V, Dang
openaire +2 more sources
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
Acta Pharmaceutica Sinica B, 2022 The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes.
Xiaomeng Gao +10 more
doaj +1 more source