There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
core +1 more source
c-Myc Suppression of DNA Double-strand Break Repair
Neoplasia: An International Journal for Oncology Research, 2012 c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s)
Zhaozhong Li +8 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Identifying patients with de novo acute myeloid leukemia (AML) who will probably respond to the “7 + 3” induction regimen remains an unsolved clinical challenge.
Tzu-Hung Hsiao +15 more
doaj +1 more source
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]
, 2007 The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero +7 more
core +1 more source
Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions [PDF]
Genes & Cancer, 2010 The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts essential for normal embryonic development.
Felicite K, Noubissi +3 more
openaire +2 more sources
Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]
Oncogene, 2000 Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme +7 more
openaire +2 more sources
FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]
Journal of Biological Chemistry, 2015 FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei +5 more
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Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation [PDF]
Blood, 2019 Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. When aberrantly activated, Gfi1 may function as a weak oncoprotein in the lymphoid system, but collaborate strongly with c-Myc in lymphomagenesis. c-Myc is a transcription factor that is frequently activated in human cancers including leukemia and lymphoma ...
Zhang, Yangyang, Dong, Fan
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c-Myc accelerates S-phase and requires WRN to avoid replication stress.
PLoS ONE, 2009 c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson +3 more
doaj +1 more source
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. [PDF]
PLoS ONE, 2012 Although tumor-associated macrophages (TAMs) are involved in tumor growth and metastasis, the mechanisms controlling their pro-tumoral activities remain largely unknown.
Oscar M Pello +8 more
doaj +1 more source