Results 51 to 60 of about 23,377,083 (210)

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2018
Background The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy ...
Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero   +5 more
doaj   +1 more source

Western Blot for c-MYC

, 2020
Western blot analysis was performed according to standard procedures. The primary antibodies used were anti-c-Myc (Abcam ab32072) and anti-GAPDH (Santa Cruz sc47724), each at a dilution of 1:1000.
Morito Kurata (8164626)
core   +1 more source

PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies

Cells
MYCN and c-MYC are critical driver oncogenes in several childhood cancers, including neuroblastoma. Currently, the clinical development of MYC inhibitors has been hindered by the intrinsically disordered structure of MYC proteins, which lack well-defined
Sukriti Krishan, Jessica Koach, Taylor Lim, Kenny Yeo, Faith Cheong, Jie-Si Luo, Hassina Massudi, Xiaomian Gao, Sopheakwealthy Heangsarath, Andrew J. Kueh, Marco J. Herold, Belamy B. Cheung, Glenn M. Marshall   +12 more
doaj   +1 more source

Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation. [PDF]

PLoS ONE, 2014
Nowadays, drug resistance still represents a major obstacle to successful acute myeloid leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we found that high expression of c-Myc was one of the cytogenetic characteristics
Xiao-Na Pan, Jia-Jie Chen, Le-Xun Wang, Ruo-Zhi Xiao, Ling-Ling Liu, Zhi-Gang Fang, Quentin Liu, Zi-Jie Long, Dong-Jun Lin   +8 more
doaj   +1 more source

c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]

, 2007
Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Rachel G. Berkson, Chiou-Nan Shiue, Anthony P. H. Wright   +2 more
core  

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
The c-myc proto-oncogene encodes a transcription factor that is involved in cell proliferation, growth, differentiation, and apoptosis. Previous studies on the regulation of hepatic c-myc have focused on control of its mRNA expression, which generally correlates with hepatocyte proliferation during both liver development and liver regeneration. However,
Sanders, Jennifer A., Gruppuso, Philip A.   +1 more
openaire   +2 more sources

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation [PDF]

Proceedings of the National Academy of Sciences, 2008
The transcription factor c-Myc is essential for cellular proliferation and is one of the most frequently activated oncogenes, but the molecular mechanism mediating its critical role in transformation is unclear. Like c-Myc, multifunctional nucleophosmin (NPM) is tightly regulated during proliferation and is overexpressed in several different types of ...
Zhaoliang, Li, David, Boone, Stephen R, Hann   +2 more
openaire   +2 more sources

Direct Activation of HSP90A Transcription by c-Myc Contributes to c-Myc-induced Transformation [PDF]

Journal of Biological Chemistry, 2004
The c-myc proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and implicated in inducing tumorigenesis. Understanding the function of c-Myc and its role in cancer depends upon the identification of c-Myc target genes.
Teng, Shu-Chun, Chen, Yung-Yi, Su, Yi-Ning, Chou, Po-Chien, Chiang, Yu-Chi, Tseng, Shun-Fu, Wu, Kou-Juey   +6 more
openaire   +2 more sources

DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein

Molecular Cancer, 2008
Background C-Myc is a short-lived oncoprotein that is destroyed by ubiquitin-mediated proteolysis. Dysregulated accumulation of c-Myc commonly occurs in human cancers. Some of those cases with the dysregulated c-Myc protein accumulation are attributed to
Wang Yu, Shang Zeng-Fu, Huo Yan-Ying, Zhang Shi-Meng, Xu Qin-Zhi, Yang Dong-Yan, An Jing, Wu De-Chang, Zhou Ping-Kun   +8 more
doaj   +1 more source