Results 61 to 70 of about 23,377,083 (210)

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations [PDF]

Cell, 2008
Chromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in Burkitt's lymphomas in humans and plasmacytomas in mice.
Robbiani, Davide, Bothmer, Anne, Callen, Elsa, Reina-San-Martin, Bernardo, Dorsett, Yair, Difilippantonio, Simone, Bolland, Daniel, Chen, Hua Tang, Corcoran, Anne, Nussenzweig, André, Nussenzweig, Michel   +10 more
openaire   +3 more sources

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis-0

, 2011
Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022), Stella Pelengaris (71018), Linda Cheung (71020), Michael Khan (71023), Sylvie Abouna (71019), Vasiliki Ifandi (71021)   +5 more
core   +1 more source

USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc

Journal of Experimental & Clinical Cancer Research, 2021
Background c-Myc, a well-established oncogene, plays an important role in the initiation and progression of various cancers, including prostate cancer. However, its mechanism in cancer cell remains largely unknown and whether there exist a deubiquitinase
Jianchao Ge, Wandong Yu, Junhong Li, Hangbin Ma, Pengyu Wang, Yinghao Zhou, Yang Wang, Jun Zhang, Guowei Shi   +8 more
doaj   +1 more source

SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62 [PDF]

Oncogene, 2015
Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosphorylating c-Myc Ser62.
W, Wang, P, Liao, M, Shen, T, Chen, Y, Chen, Y, Li, X, Lin, X, Ge, P, Wang   +8 more
openaire   +2 more sources

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis-1

, 2011
Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022), Stella Pelengaris (71018), Linda Cheung (71020), Michael Khan (71023), Sylvie Abouna (71019), Vasiliki Ifandi (71021)   +5 more
core   +1 more source

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

Frontiers in Genetics
BackgroundProto-oncogenes are abnormally activated in nearly all types of tumors. However, the epigenetic mechanism of proto-oncogene activation has not yet been well elucidated.MethodsThe present study involved the construction of a double-stranded cDNA
Xuming Hu, Xuming Hu, Xuming Hu, Ye Wei, Meiying Zhang, Chunfeng Dou, Liping Wang, Gul Zaib, Huixian Wu, Wang Guo, Xiaoyuan Wang, Shihao Chen, Qi Xu, Qi Xu, Qi Xu, Mingzhou Guo, Hengmi Cui, Hengmi Cui, Hengmi Cui, Hengmi Cui   +19 more
doaj   +1 more source

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Cell Death and Disease, 2021
Dysregulation of transforming growth factor-beta (TGFβ) signaling has been implicated in liver carcinogenesis with both tumor promoting and inhibiting activities.
Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen   +8 more
doaj   +1 more source

Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription [PDF]

Oncogene, 2012
The transcription factor c-Myc has a critical role in cell proliferation and growth. The control of ribosome biogenesis by c-Myc through the regulation of transcription mediated by all three RNA polymerases is essential for c-Myc-driven proliferation. Specifically, in the nucleolus, c-Myc has been shown to be recruited to ribosomal DNA and activate RNA
Z, Li, S R, Hann
openaire   +2 more sources

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis-2

, 2011
Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022), Stella Pelengaris (71018), Linda Cheung (71020), Michael Khan (71023), Sylvie Abouna (71019), Vasiliki Ifandi (71021)   +5 more
core   +1 more source

C-MYC aberrations as prognostic factors in diffuse large B-cell lymphoma: a meta-analysis of epidemiological studies.

PLoS ONE, 2014
ObjectivesVarious studies have investigated the prognostic value of C-MYC aberrations in diffuse large B-cell lymphoma (DLBCL). However, the role of C-MYC as an independent prognostic factor in clinical practice remains controversial. A systematic review
Kuangguo Zhou, Danmei Xu, Yang Cao, Jue Wang, Yunfan Yang, Mei Huang   +5 more
doaj   +1 more source