Results 1 to 10 of about 79,488 (241)

Notch: From fly wings to human hematological tumors [PDF]

Archive of Oncology, 2009
Notch history begins in 1919 with Thomas Hunt Morgan studies on fruit fly mutants. From then, this gene aroused lively interest in the scientific community since it is involved in a wide variety of processes, including morphogenesis, tissue homeostasis ...
Mirandola Leonardo, Larocca Sara, Rea Katia, Palma Giovanni, Comi Paola, Chiaramonte Raffaella   +5 more
doaj   +1 more source

Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

Neoplasia: An International Journal for Oncology Research, 2013
PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis.
Ulrike Weirauch, Nadine Beckmann, Maren Thomas, Arnold Grünweller, Kilian Huber, Franz Bracher, Roland K. Hartmann, Achim Aigner   +7 more
doaj   +3 more sources

N-Myc Differentially Regulates Expression of MXI1 Isoforms in Neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2013
Amplification of the MYCN proto-oncogene is associated with a poor prognosis in patients with metastatic neuroblastoma (NB). MYCN encodes the N-Myc protein, a transcriptional regulator that dimerizes with the Max transcription factor, binds to E-box DNA ...
Michael B. Armstrong, Rajen J. Mody, D. Christian Ellis, Adam B. Hill, David A. Erichsen, Daniel S. Wechsler   +5 more
doaj   +1 more source

Proteomic profiling of oleamide-mediated polarization in a primary human monocyte-derived tumor-associated macrophages (TAMs) model: a functional analysis [PDF]

PeerJ
Background Tumor-associated macrophages (TAMs) play a critical function in the development of tumors and are associated with protumor M2 phenotypes. Shifting TAMs towards antitumor M1 phenotypes holds promise for tumor immunotherapy.
Prapakorn Wisitpongpun, Watunyoo Buakaew, Sutatip Pongcharoen, Napaporn Apiratmateekul, Pachuen Potup, Krai Daowtak, Sucheewin Krobthong, Yodying Yingchutrakul, Paul J. Brindley, Kanchana Usuwanthim   +9 more
doaj   +2 more sources

Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma

Indian Journal of Dental Research, 2018
Aim: The aim of this study is to explore the prognostic significance and clinicopathological correlations of the Wnt pathway genes in a cohort of surgically treated patients with oral squamous cell carcinoma (OSCC) patients.
Madhulaxmi Marimuthu, Manoharan Andiappan, Abdul Wahab, M R Muthusekhar, Anandan Balakrishnan, Sambandham Shanmugam   +5 more
doaj   +1 more source

CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC

BBA Advances
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy.
Li Li, Jiaxiu Xie, Jinxing Liang, Hua Su, Xiaoju Shen, Xiaoxiang Mo, Xinli Lin, Weidan Tan, Kun Wu, Fucui Zhu, Li Wang, Ying Liu   +11 more
doaj   +1 more source

Molecular cloning and analysis of Myc modulator 1 (Mm-1) from Bufo gargarizans (Amphibia: Anura)

Zoologia (Curitiba), 2010
The protein of Myc modulator 1 (Mm-1) has been reported to repress the transcriptional activity of the proto-oncogene c-Myc in humans. Moreover, it was shown to be the subunit 5 of human prefoldin (PFD).
Ning Wang, Rui Jia, Jing J. Wang, Liu W. Nie   +3 more
doaj   +1 more source

Prevalence of c-myc expression in breast lesions associated with microcalcifications detected by routine mammography

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications ...
Renato Coimbra Mazzini, Simone Elias, Afonso Celso Pinto Nazário, Cláudio Kemp, Ângela Flávia Logullo   +4 more
doaj   +1 more source

PATTERNFINDER: combined analysis of DNA regulatory sequences and double-helix stability

BMC Bioinformatics, 2004
Background Regulatory regions that function in DNA replication and gene transcription contain specific sequences that bind proteins as well as less-specific sequences in which the double helix is often easy to unwind.
Huang Yanlin, Kowalski David
doaj   +1 more source

Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.

PLoS ONE, 2014
The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and ...
Xiaotian Zhang, Yi Wang, Wenjing Hu, Dongye Li, Zhongmin Zhou, Defeng Pan, Wanling Wu, Tongda Xu   +7 more
doaj   +1 more source